Cargando…
Role of NMDA Receptor-Mediated Glutamatergic Signaling in Chronic and Acute Neuropathologies
N-Methyl-D-aspartate receptors (NMDARs) have two opposing roles in the brain. On the one hand, NMDARs control critical events in the formation and development of synaptic organization and synaptic plasticity. On the other hand, the overactivation of NMDARs can promote neuronal death in neuropatholog...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007376/ https://www.ncbi.nlm.nih.gov/pubmed/27630777 http://dx.doi.org/10.1155/2016/2701526 |
_version_ | 1782451198618501120 |
---|---|
author | Carvajal, Francisco J. Mattison, Hayley A. Cerpa, Waldo |
author_facet | Carvajal, Francisco J. Mattison, Hayley A. Cerpa, Waldo |
author_sort | Carvajal, Francisco J. |
collection | PubMed |
description | N-Methyl-D-aspartate receptors (NMDARs) have two opposing roles in the brain. On the one hand, NMDARs control critical events in the formation and development of synaptic organization and synaptic plasticity. On the other hand, the overactivation of NMDARs can promote neuronal death in neuropathological conditions. Ca(2+) influx acts as a primary modulator after NMDAR channel activation. An imbalance in Ca(2+) homeostasis is associated with several neurological diseases including schizophrenia, Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis. These chronic conditions have a lengthy progression depending on internal and external factors. External factors such as acute episodes of brain damage are associated with an earlier onset of several of these chronic mental conditions. Here, we will review some of the current evidence of how traumatic brain injury can hasten the onset of several neurological conditions, focusing on the role of NMDAR distribution and the functional consequences in calcium homeostasis associated with synaptic dysfunction and neuronal death present in this group of chronic diseases. |
format | Online Article Text |
id | pubmed-5007376 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-50073762016-09-14 Role of NMDA Receptor-Mediated Glutamatergic Signaling in Chronic and Acute Neuropathologies Carvajal, Francisco J. Mattison, Hayley A. Cerpa, Waldo Neural Plast Review Article N-Methyl-D-aspartate receptors (NMDARs) have two opposing roles in the brain. On the one hand, NMDARs control critical events in the formation and development of synaptic organization and synaptic plasticity. On the other hand, the overactivation of NMDARs can promote neuronal death in neuropathological conditions. Ca(2+) influx acts as a primary modulator after NMDAR channel activation. An imbalance in Ca(2+) homeostasis is associated with several neurological diseases including schizophrenia, Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis. These chronic conditions have a lengthy progression depending on internal and external factors. External factors such as acute episodes of brain damage are associated with an earlier onset of several of these chronic mental conditions. Here, we will review some of the current evidence of how traumatic brain injury can hasten the onset of several neurological conditions, focusing on the role of NMDAR distribution and the functional consequences in calcium homeostasis associated with synaptic dysfunction and neuronal death present in this group of chronic diseases. Hindawi Publishing Corporation 2016 2016-08-18 /pmc/articles/PMC5007376/ /pubmed/27630777 http://dx.doi.org/10.1155/2016/2701526 Text en Copyright © 2016 Francisco J. Carvajal et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Carvajal, Francisco J. Mattison, Hayley A. Cerpa, Waldo Role of NMDA Receptor-Mediated Glutamatergic Signaling in Chronic and Acute Neuropathologies |
title | Role of NMDA Receptor-Mediated Glutamatergic Signaling in Chronic and Acute Neuropathologies |
title_full | Role of NMDA Receptor-Mediated Glutamatergic Signaling in Chronic and Acute Neuropathologies |
title_fullStr | Role of NMDA Receptor-Mediated Glutamatergic Signaling in Chronic and Acute Neuropathologies |
title_full_unstemmed | Role of NMDA Receptor-Mediated Glutamatergic Signaling in Chronic and Acute Neuropathologies |
title_short | Role of NMDA Receptor-Mediated Glutamatergic Signaling in Chronic and Acute Neuropathologies |
title_sort | role of nmda receptor-mediated glutamatergic signaling in chronic and acute neuropathologies |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007376/ https://www.ncbi.nlm.nih.gov/pubmed/27630777 http://dx.doi.org/10.1155/2016/2701526 |
work_keys_str_mv | AT carvajalfranciscoj roleofnmdareceptormediatedglutamatergicsignalinginchronicandacuteneuropathologies AT mattisonhayleya roleofnmdareceptormediatedglutamatergicsignalinginchronicandacuteneuropathologies AT cerpawaldo roleofnmdareceptormediatedglutamatergicsignalinginchronicandacuteneuropathologies |