In-Vivo Proton Magnetic Resonance Spectroscopy of 2-Hydroxyglutarate in Isocitrate Dehydrogenase-Mutated Gliomas: A Technical Review for Neuroradiologists

The diagnostic and prognostic potential of an onco-metabolite, 2-hydroxyglutarate (2HG) as a proton magnetic resonance spectroscopy (1H-MRS) detectable biomarker of the isocitrate dehydrogenase (IDH)-mutated (IDH-MT) gliomas has drawn attention of neuroradiologists recently. However, due to severe s...

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Detalles Bibliográficos
Autores principales: Kim, Hyeonjin, Kim, Sungjin, Lee, Hyeong Hun, Heo, Hwon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Radiology 2016
Materias:
Neuroimaging and Head & Neck
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007388/
https://www.ncbi.nlm.nih.gov/pubmed/27587950
http://dx.doi.org/10.3348/kjr.2016.17.5.620
Descripción
Sumario:The diagnostic and prognostic potential of an onco-metabolite, 2-hydroxyglutarate (2HG) as a proton magnetic resonance spectroscopy (1H-MRS) detectable biomarker of the isocitrate dehydrogenase (IDH)-mutated (IDH-MT) gliomas has drawn attention of neuroradiologists recently. However, due to severe spectral overlap with background signals, quantification of 2HG can be very challenging. In this technical review for neuroradiologists, first, the biochemistry of 2HG and its significance in the diagnosis of IDH-MT gliomas are summarized. Secondly, various 1H-MRS methods used in the previous studies are outlined. Finally, wereview previous in vivo studies, and discuss the current status of 1H-MRS in the diagnosis of IDH-MT gliomas.

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