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A Comparison of Substantia Nigra T1 Hyperintensity in Parkinson's Disease Dementia, Alzheimer's Disease and Age-Matched Controls: Volumetric Analysis of Neuromelanin Imaging

OBJECTIVE: Neuromelanin loss of substantia nigra (SN) can be visualized as a T1 signal reduction on T1-weighted high-resolution imaging. We investigated whether volumetric analysis of T1 hyperintensity for SN could be used to differentiate between Parkinson's disease dementia (PDD), Alzheimer&#...

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Autores principales: Moon, Won-Jin, Park, Ju-Yeon, Yun, Won-Sung, Jeon, Ji Yeong, Moon, Yeon Sil, Kim, Heejin, Kwak, Ki-Chang, Lee, Jong-Min, Han, Seol-Heui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Radiology 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007389/
https://www.ncbi.nlm.nih.gov/pubmed/27587951
http://dx.doi.org/10.3348/kjr.2016.17.5.633
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author Moon, Won-Jin
Park, Ju-Yeon
Yun, Won-Sung
Jeon, Ji Yeong
Moon, Yeon Sil
Kim, Heejin
Kwak, Ki-Chang
Lee, Jong-Min
Han, Seol-Heui
author_facet Moon, Won-Jin
Park, Ju-Yeon
Yun, Won-Sung
Jeon, Ji Yeong
Moon, Yeon Sil
Kim, Heejin
Kwak, Ki-Chang
Lee, Jong-Min
Han, Seol-Heui
author_sort Moon, Won-Jin
collection PubMed
description OBJECTIVE: Neuromelanin loss of substantia nigra (SN) can be visualized as a T1 signal reduction on T1-weighted high-resolution imaging. We investigated whether volumetric analysis of T1 hyperintensity for SN could be used to differentiate between Parkinson's disease dementia (PDD), Alzheimer's disease (AD) and age-matched controls. MATERIALS AND METHODS: This retrospective study enrolled 10 patients with PDD, 18 patients with AD, and 13 age-matched healthy elderly controls. MR imaging was performed at 3 tesla. To measure the T1 hyperintense area of SN, we obtained an axial thin section high-resolution T1-weighted fast spin echo sequence. The volumes of interest for the T1 hyperintense SN were drawn onto heavily T1-weighted FSE sequences through midbrain level, using the MIPAV software. The measurement differences were tested using the Kruskal-Wallis test followed by a post hoc comparison. RESULTS: A comparison of the three groups showed significant differences in terms of volume of T1 hyperintensity (p < 0.001, Bonferroni corrected). The volume of T1 hyperintensity was significantly lower in PDD than in AD and normal controls (p < 0.005, Bonferroni corrected). However, the volume of T1 hyperintensity was not different between AD and normal controls (p = 0.136, Bonferroni corrected). CONCLUSION: The volumetric measurement of the T1 hyperintensity of SN can be an imaging marker for evaluating neuromelanin loss in neurodegenerative diseases and a differential in PDD and AD cases.
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spelling pubmed-50073892016-09-01 A Comparison of Substantia Nigra T1 Hyperintensity in Parkinson's Disease Dementia, Alzheimer's Disease and Age-Matched Controls: Volumetric Analysis of Neuromelanin Imaging Moon, Won-Jin Park, Ju-Yeon Yun, Won-Sung Jeon, Ji Yeong Moon, Yeon Sil Kim, Heejin Kwak, Ki-Chang Lee, Jong-Min Han, Seol-Heui Korean J Radiol Neuroimaging and Head & Neck OBJECTIVE: Neuromelanin loss of substantia nigra (SN) can be visualized as a T1 signal reduction on T1-weighted high-resolution imaging. We investigated whether volumetric analysis of T1 hyperintensity for SN could be used to differentiate between Parkinson's disease dementia (PDD), Alzheimer's disease (AD) and age-matched controls. MATERIALS AND METHODS: This retrospective study enrolled 10 patients with PDD, 18 patients with AD, and 13 age-matched healthy elderly controls. MR imaging was performed at 3 tesla. To measure the T1 hyperintense area of SN, we obtained an axial thin section high-resolution T1-weighted fast spin echo sequence. The volumes of interest for the T1 hyperintense SN were drawn onto heavily T1-weighted FSE sequences through midbrain level, using the MIPAV software. The measurement differences were tested using the Kruskal-Wallis test followed by a post hoc comparison. RESULTS: A comparison of the three groups showed significant differences in terms of volume of T1 hyperintensity (p < 0.001, Bonferroni corrected). The volume of T1 hyperintensity was significantly lower in PDD than in AD and normal controls (p < 0.005, Bonferroni corrected). However, the volume of T1 hyperintensity was not different between AD and normal controls (p = 0.136, Bonferroni corrected). CONCLUSION: The volumetric measurement of the T1 hyperintensity of SN can be an imaging marker for evaluating neuromelanin loss in neurodegenerative diseases and a differential in PDD and AD cases. The Korean Society of Radiology 2016 2016-08-23 /pmc/articles/PMC5007389/ /pubmed/27587951 http://dx.doi.org/10.3348/kjr.2016.17.5.633 Text en Copyright © 2016 The Korean Society of Radiology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Neuroimaging and Head & Neck
Moon, Won-Jin
Park, Ju-Yeon
Yun, Won-Sung
Jeon, Ji Yeong
Moon, Yeon Sil
Kim, Heejin
Kwak, Ki-Chang
Lee, Jong-Min
Han, Seol-Heui
A Comparison of Substantia Nigra T1 Hyperintensity in Parkinson's Disease Dementia, Alzheimer's Disease and Age-Matched Controls: Volumetric Analysis of Neuromelanin Imaging
title A Comparison of Substantia Nigra T1 Hyperintensity in Parkinson's Disease Dementia, Alzheimer's Disease and Age-Matched Controls: Volumetric Analysis of Neuromelanin Imaging
title_full A Comparison of Substantia Nigra T1 Hyperintensity in Parkinson's Disease Dementia, Alzheimer's Disease and Age-Matched Controls: Volumetric Analysis of Neuromelanin Imaging
title_fullStr A Comparison of Substantia Nigra T1 Hyperintensity in Parkinson's Disease Dementia, Alzheimer's Disease and Age-Matched Controls: Volumetric Analysis of Neuromelanin Imaging
title_full_unstemmed A Comparison of Substantia Nigra T1 Hyperintensity in Parkinson's Disease Dementia, Alzheimer's Disease and Age-Matched Controls: Volumetric Analysis of Neuromelanin Imaging
title_short A Comparison of Substantia Nigra T1 Hyperintensity in Parkinson's Disease Dementia, Alzheimer's Disease and Age-Matched Controls: Volumetric Analysis of Neuromelanin Imaging
title_sort comparison of substantia nigra t1 hyperintensity in parkinson's disease dementia, alzheimer's disease and age-matched controls: volumetric analysis of neuromelanin imaging
topic Neuroimaging and Head & Neck
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007389/
https://www.ncbi.nlm.nih.gov/pubmed/27587951
http://dx.doi.org/10.3348/kjr.2016.17.5.633
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