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Treatment with recombinant human bone morphogenetic protein 7 leads to a transient induction of neutralizing autoantibodies in a subset of patients

BACKGROUND: Recombinant human bone morphogenetic protein 7 (rhBMP7) is applied for treatment of bone fractures, especially tibial non-unions. Its application may induce autoantibodies (aAB) affecting the targeted and endogenous signaling pathways and in turn negatively impact treatment efficacy. MET...

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Detalles Bibliográficos
Autores principales:	Schuette, Andrea, Moghaddam, Arash, Seemann, Petra, Duda, Georg N., Schmidmaier, Gerhard, Schomburg, Lutz
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2016
Materias:	Regular Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007422/ https://www.ncbi.nlm.nih.gov/pubmed/27617228 http://dx.doi.org/10.1016/j.bbacli.2016.08.001

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