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VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington's disease
Mutant Huntingtin (mtHtt) causes neurodegeneration in Huntington's disease (HD) by evoking defects in the mitochondria, but the underlying mechanisms remains elusive. Our proteomic analysis identifies valosin-containing protein (VCP) as an mtHtt-binding protein on the mitochondria. Here we show...
Autores principales: | Guo, Xing, Sun, XiaoYan, Hu, Di, Wang, Ya-Juan, Fujioka, Hisashi, Vyas, Rajan, Chakrapani, Sudha, Joshi, Amit Umesh, Luo, Yu, Mochly-Rosen, Daria, Qi, Xin |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007466/ https://www.ncbi.nlm.nih.gov/pubmed/27561680 http://dx.doi.org/10.1038/ncomms12646 |
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