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Heterophile Antibody Interference led to Unneeded Chemotherapy in a Testicular Cancer Patient

Human heterophile antibodies may develop after infection or contact with animal tissues or animal serum products. These antibodies have the capacity to bind to the animal immunoglobulins used in immunoassays leading to erroneous results. We here report a case of a testicular germ cell tumor patient...

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Autores principales: Soares, Daniele G., Millot, Françoise, Lacroix, Isabelle, Lotz, Jean-Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007586/
https://www.ncbi.nlm.nih.gov/pubmed/27617210
http://dx.doi.org/10.1016/j.eucr.2016.07.006
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author Soares, Daniele G.
Millot, Françoise
Lacroix, Isabelle
Lotz, Jean-Pierre
author_facet Soares, Daniele G.
Millot, Françoise
Lacroix, Isabelle
Lotz, Jean-Pierre
author_sort Soares, Daniele G.
collection PubMed
description Human heterophile antibodies may develop after infection or contact with animal tissues or animal serum products. These antibodies have the capacity to bind to the animal immunoglobulins used in immunoassays leading to erroneous results. We here report a case of a testicular germ cell tumor patient who developed heterophile antibodies during the surveillance period of his disease. Following false-positive results of human chorionic gonadotropin (hCG) he received unneeded chemotherapy. This article also stresses the problem of using serum tumor markers without no major imaging abnormalities to diagnose a patients' relapse.
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spelling pubmed-50075862016-09-09 Heterophile Antibody Interference led to Unneeded Chemotherapy in a Testicular Cancer Patient Soares, Daniele G. Millot, Françoise Lacroix, Isabelle Lotz, Jean-Pierre Urol Case Rep Oncology Human heterophile antibodies may develop after infection or contact with animal tissues or animal serum products. These antibodies have the capacity to bind to the animal immunoglobulins used in immunoassays leading to erroneous results. We here report a case of a testicular germ cell tumor patient who developed heterophile antibodies during the surveillance period of his disease. Following false-positive results of human chorionic gonadotropin (hCG) he received unneeded chemotherapy. This article also stresses the problem of using serum tumor markers without no major imaging abnormalities to diagnose a patients' relapse. Elsevier 2016-08-26 /pmc/articles/PMC5007586/ /pubmed/27617210 http://dx.doi.org/10.1016/j.eucr.2016.07.006 Text en © 2016 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Oncology
Soares, Daniele G.
Millot, Françoise
Lacroix, Isabelle
Lotz, Jean-Pierre
Heterophile Antibody Interference led to Unneeded Chemotherapy in a Testicular Cancer Patient
title Heterophile Antibody Interference led to Unneeded Chemotherapy in a Testicular Cancer Patient
title_full Heterophile Antibody Interference led to Unneeded Chemotherapy in a Testicular Cancer Patient
title_fullStr Heterophile Antibody Interference led to Unneeded Chemotherapy in a Testicular Cancer Patient
title_full_unstemmed Heterophile Antibody Interference led to Unneeded Chemotherapy in a Testicular Cancer Patient
title_short Heterophile Antibody Interference led to Unneeded Chemotherapy in a Testicular Cancer Patient
title_sort heterophile antibody interference led to unneeded chemotherapy in a testicular cancer patient
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007586/
https://www.ncbi.nlm.nih.gov/pubmed/27617210
http://dx.doi.org/10.1016/j.eucr.2016.07.006
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