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Heterophile Antibody Interference led to Unneeded Chemotherapy in a Testicular Cancer Patient
Human heterophile antibodies may develop after infection or contact with animal tissues or animal serum products. These antibodies have the capacity to bind to the animal immunoglobulins used in immunoassays leading to erroneous results. We here report a case of a testicular germ cell tumor patient...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007586/ https://www.ncbi.nlm.nih.gov/pubmed/27617210 http://dx.doi.org/10.1016/j.eucr.2016.07.006 |
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author | Soares, Daniele G. Millot, Françoise Lacroix, Isabelle Lotz, Jean-Pierre |
author_facet | Soares, Daniele G. Millot, Françoise Lacroix, Isabelle Lotz, Jean-Pierre |
author_sort | Soares, Daniele G. |
collection | PubMed |
description | Human heterophile antibodies may develop after infection or contact with animal tissues or animal serum products. These antibodies have the capacity to bind to the animal immunoglobulins used in immunoassays leading to erroneous results. We here report a case of a testicular germ cell tumor patient who developed heterophile antibodies during the surveillance period of his disease. Following false-positive results of human chorionic gonadotropin (hCG) he received unneeded chemotherapy. This article also stresses the problem of using serum tumor markers without no major imaging abnormalities to diagnose a patients' relapse. |
format | Online Article Text |
id | pubmed-5007586 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-50075862016-09-09 Heterophile Antibody Interference led to Unneeded Chemotherapy in a Testicular Cancer Patient Soares, Daniele G. Millot, Françoise Lacroix, Isabelle Lotz, Jean-Pierre Urol Case Rep Oncology Human heterophile antibodies may develop after infection or contact with animal tissues or animal serum products. These antibodies have the capacity to bind to the animal immunoglobulins used in immunoassays leading to erroneous results. We here report a case of a testicular germ cell tumor patient who developed heterophile antibodies during the surveillance period of his disease. Following false-positive results of human chorionic gonadotropin (hCG) he received unneeded chemotherapy. This article also stresses the problem of using serum tumor markers without no major imaging abnormalities to diagnose a patients' relapse. Elsevier 2016-08-26 /pmc/articles/PMC5007586/ /pubmed/27617210 http://dx.doi.org/10.1016/j.eucr.2016.07.006 Text en © 2016 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Oncology Soares, Daniele G. Millot, Françoise Lacroix, Isabelle Lotz, Jean-Pierre Heterophile Antibody Interference led to Unneeded Chemotherapy in a Testicular Cancer Patient |
title | Heterophile Antibody Interference led to Unneeded Chemotherapy in a Testicular Cancer Patient |
title_full | Heterophile Antibody Interference led to Unneeded Chemotherapy in a Testicular Cancer Patient |
title_fullStr | Heterophile Antibody Interference led to Unneeded Chemotherapy in a Testicular Cancer Patient |
title_full_unstemmed | Heterophile Antibody Interference led to Unneeded Chemotherapy in a Testicular Cancer Patient |
title_short | Heterophile Antibody Interference led to Unneeded Chemotherapy in a Testicular Cancer Patient |
title_sort | heterophile antibody interference led to unneeded chemotherapy in a testicular cancer patient |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007586/ https://www.ncbi.nlm.nih.gov/pubmed/27617210 http://dx.doi.org/10.1016/j.eucr.2016.07.006 |
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