One-pot synthesis of (−)-Ambrox

(−)-Ambrox is recognised as the prototype of all ambergris odorants. Widely used in perfumery, (−)-Ambrox is an important ingredient due to its unique scent and excellent fixative function. An environmentally friendly and practical preparation of (−)-Ambrox is still unavailable at present although a...

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Detalles Bibliográficos
Autores principales: Yang, Shaoxiang, Tian, Hongyu, Sun, Baoguo, Liu, Yongguo, Hao, Yanfeng, Lv, Yanyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007644/
https://www.ncbi.nlm.nih.gov/pubmed/27581945
http://dx.doi.org/10.1038/srep32650
Descripción
Sumario:(−)-Ambrox is recognised as the prototype of all ambergris odorants. Widely used in perfumery, (−)-Ambrox is an important ingredient due to its unique scent and excellent fixative function. An environmentally friendly and practical preparation of (−)-Ambrox is still unavailable at present although a lot of attention has been paid to this hot research topic for many years. A one-pot synthesis of (−)-Ambrox was studied starting from (−)-sclareol through oxidation with hydrogen peroxide in the presence of a quaternary ammonium phosphomolybdate catalyst {[C(5)H(5)NC(16)H(33)] [H(2)PMo(12)O(40)]}, which gave the product a 20% overall yield.

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