One-pot synthesis of (−)-Ambrox

(−)-Ambrox is recognised as the prototype of all ambergris odorants. Widely used in perfumery, (−)-Ambrox is an important ingredient due to its unique scent and excellent fixative function. An environmentally friendly and practical preparation of (−)-Ambrox is still unavailable at present although a...

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Autores principales: Yang, Shaoxiang, Tian, Hongyu, Sun, Baoguo, Liu, Yongguo, Hao, Yanfeng, Lv, Yanyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007644/
https://www.ncbi.nlm.nih.gov/pubmed/27581945
http://dx.doi.org/10.1038/srep32650
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author Yang, Shaoxiang
Tian, Hongyu
Sun, Baoguo
Liu, Yongguo
Hao, Yanfeng
Lv, Yanyu
author_facet Yang, Shaoxiang
Tian, Hongyu
Sun, Baoguo
Liu, Yongguo
Hao, Yanfeng
Lv, Yanyu
author_sort Yang, Shaoxiang
collection PubMed
description (−)-Ambrox is recognised as the prototype of all ambergris odorants. Widely used in perfumery, (−)-Ambrox is an important ingredient due to its unique scent and excellent fixative function. An environmentally friendly and practical preparation of (−)-Ambrox is still unavailable at present although a lot of attention has been paid to this hot research topic for many years. A one-pot synthesis of (−)-Ambrox was studied starting from (−)-sclareol through oxidation with hydrogen peroxide in the presence of a quaternary ammonium phosphomolybdate catalyst {[C(5)H(5)NC(16)H(33)] [H(2)PMo(12)O(40)]}, which gave the product a 20% overall yield.
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spelling pubmed-50076442016-09-08 One-pot synthesis of (−)-Ambrox Yang, Shaoxiang Tian, Hongyu Sun, Baoguo Liu, Yongguo Hao, Yanfeng Lv, Yanyu Sci Rep Article (−)-Ambrox is recognised as the prototype of all ambergris odorants. Widely used in perfumery, (−)-Ambrox is an important ingredient due to its unique scent and excellent fixative function. An environmentally friendly and practical preparation of (−)-Ambrox is still unavailable at present although a lot of attention has been paid to this hot research topic for many years. A one-pot synthesis of (−)-Ambrox was studied starting from (−)-sclareol through oxidation with hydrogen peroxide in the presence of a quaternary ammonium phosphomolybdate catalyst {[C(5)H(5)NC(16)H(33)] [H(2)PMo(12)O(40)]}, which gave the product a 20% overall yield. Nature Publishing Group 2016-09-01 /pmc/articles/PMC5007644/ /pubmed/27581945 http://dx.doi.org/10.1038/srep32650 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Yang, Shaoxiang
Tian, Hongyu
Sun, Baoguo
Liu, Yongguo
Hao, Yanfeng
Lv, Yanyu
One-pot synthesis of (−)-Ambrox
title One-pot synthesis of (−)-Ambrox
title_full One-pot synthesis of (−)-Ambrox
title_fullStr One-pot synthesis of (−)-Ambrox
title_full_unstemmed One-pot synthesis of (−)-Ambrox
title_short One-pot synthesis of (−)-Ambrox
title_sort one-pot synthesis of (−)-ambrox
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007644/
https://www.ncbi.nlm.nih.gov/pubmed/27581945
http://dx.doi.org/10.1038/srep32650
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