Physapubescin selectively induces apoptosis in VHL-null renal cell carcinoma cells through down-regulation of HIF-2α and inhibits tumor growth

We have purified physapubescin, a predominant steroidal lactone, from medicinal plant Physalis pubescens L., commonly named as “hairy groundcherry” in English and “Deng-Long-Cao” in Chinese. Von Hippel-Lindau (VHL)-null 786-O, RCC4 and A498 Renal Cell Carcinoma (RCC) cell lines expressing high level...

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Detalles Bibliográficos
Autores principales: Chen, Lixia, Xia, Guiyang, Qiu, Feng, Wu, Chunli, Denmon, Andria P., Zi, Xiaolin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007653/
https://www.ncbi.nlm.nih.gov/pubmed/27581364
http://dx.doi.org/10.1038/srep32582

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007653/
https://www.ncbi.nlm.nih.gov/pubmed/27581364
http://dx.doi.org/10.1038/srep32582

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