The cancer-associated CTCFL/BORIS protein targets multiple classes of genomic repeats, with a distinct binding and functional preference for humanoid-specific SVA transposable elements

BACKGROUND: A common aberration in cancer is the activation of germline-specific proteins. The DNA-binding proteins among them could generate novel chromatin states, not found in normal cells. The germline-specific transcription factor BORIS/CTCFL, a paralog of chromatin architecture protein CTCF, i...

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Detalles Bibliográficos
Autores principales: Pugacheva, Elena M., Teplyakov, Evgeny, Wu, Qiongfang, Li, Jingjing, Chen, Cheng, Meng, Chengcheng, Liu, Jian, Robinson, Susan, Loukinov, Dmitry, Boukaba, Abdelhalim, Hutchins, Andrew Paul, Lobanenkov, Victor, Strunnikov, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007689/
https://www.ncbi.nlm.nih.gov/pubmed/27588042
http://dx.doi.org/10.1186/s13072-016-0084-2

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