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Erythropoietin (EPO)-receptor signaling induces cell death of primary myeloma cells in vitro

BACKGROUND: Multiple myeloma is an incurable complex disease characterized by clonal proliferation of malignant plasma cells in a hypoxic bone marrow environment. Hypoxia-dependent erythropoietin (EPO)-receptor (EPOR) signaling is central in various cancers, but the relevance of EPOR signaling in mu...

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Detalles Bibliográficos
Autores principales: Våtsveen, Thea Kristin, Sponaas, Anne-Marit, Tian, Erming, Zhang, Qing, Misund, Kristine, Sundan, Anders, Børset, Magne, Waage, Anders, Brede, Gaute
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007700/
https://www.ncbi.nlm.nih.gov/pubmed/27581518
http://dx.doi.org/10.1186/s13045-016-0306-x