Epigenetic regulation of transcription factor promoter regions by low-dose genistein through mitogen-activated protein kinase and mitogen-and-stress activated kinase 1 nongenomic signaling

BACKGROUND: The phytoestrogen, genistein at low doses nongenomically activates mitogen-activated protein kinase p44/42 (MAPK(p44/42)) via estrogen receptor alpha (ERα) leading to proliferation of human uterine leiomyoma cells. In this study, we evaluated if MAPK(p44/42) could activate downstream eff...

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Detalles Bibliográficos
Autores principales: Yu, Linda, Ham, Kyle, Gao, Xiaohua, Castro, Lysandra, Yan, Yitang, Kissling, Grace E., Tucker, Charles J., Flagler, Norris, Dong, Ray, Archer, Trevor K., Dixon, Darlene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007815/
https://www.ncbi.nlm.nih.gov/pubmed/27582276
http://dx.doi.org/10.1186/s12964-016-0141-2

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