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Suramin is a potent inhibitor of Chikungunya and Ebola virus cell entry
BACKGROUND: Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that causes high fever, rash, and recurrent arthritis in humans. It has efficiently adapted to Aedes albopictus, which also inhabits temperate regions and currently causes large outbreaks in the Caribbean and Latin America. E...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007819/ https://www.ncbi.nlm.nih.gov/pubmed/27581733 http://dx.doi.org/10.1186/s12985-016-0607-2 |
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author | Henß, Lisa Beck, Simon Weidner, Tatjana Biedenkopf, Nadine Sliva, Katja Weber, Christopher Becker, Stephan Schnierle, Barbara S. |
author_facet | Henß, Lisa Beck, Simon Weidner, Tatjana Biedenkopf, Nadine Sliva, Katja Weber, Christopher Becker, Stephan Schnierle, Barbara S. |
author_sort | Henß, Lisa |
collection | PubMed |
description | BACKGROUND: Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that causes high fever, rash, and recurrent arthritis in humans. It has efficiently adapted to Aedes albopictus, which also inhabits temperate regions and currently causes large outbreaks in the Caribbean and Latin America. Ebola virus (EBOV) is a member of the filovirus family. It causes the Ebola virus disease (EDV), formerly known as Ebola hemorrhagic fever in humans and has a mortality rate of up to 70 %. The last outbreak in Western Africa was the largest in history and has caused approximately 25,000 cases and 10,000 deaths. For both viral infections no specific treatment or licensed vaccine is currently available. The bis-hexasulfonated naphthylurea, suramin, is used as a treatment for trypanosome-caused African river blindness. As a competitive inhibitor of heparin, suramin has been described to have anti-viral activity. METHODS: We tested the activity of suramin during CHIKV or Ebola virus infection, using CHIKV and Ebola envelope glycoprotein pseudotyped lentiviral vectors and wild-type CHIKV and Ebola virus. RESULTS: Suramin efficiently inhibited CHIKV and Ebola envelope-mediated gene transfer while vesicular stomatitis virus G protein pseudotyped vectors were only marginally affected. In addition, suramin was able to inhibit wild-type CHIKV and Ebola virus replication in vitro. Inhibition occurred at early time points during CHIKV infection. CONCLUSION: Suramin, also known as Germanin or Bayer-205, is a market-authorized drug, however shows significant side effects, which probably prevents its use as a CHIKV drug, but due to the high lethality of Ebola virus infections, suramin might be valuable against Ebola infections. |
format | Online Article Text |
id | pubmed-5007819 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-50078192016-09-02 Suramin is a potent inhibitor of Chikungunya and Ebola virus cell entry Henß, Lisa Beck, Simon Weidner, Tatjana Biedenkopf, Nadine Sliva, Katja Weber, Christopher Becker, Stephan Schnierle, Barbara S. Virol J Research BACKGROUND: Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that causes high fever, rash, and recurrent arthritis in humans. It has efficiently adapted to Aedes albopictus, which also inhabits temperate regions and currently causes large outbreaks in the Caribbean and Latin America. Ebola virus (EBOV) is a member of the filovirus family. It causes the Ebola virus disease (EDV), formerly known as Ebola hemorrhagic fever in humans and has a mortality rate of up to 70 %. The last outbreak in Western Africa was the largest in history and has caused approximately 25,000 cases and 10,000 deaths. For both viral infections no specific treatment or licensed vaccine is currently available. The bis-hexasulfonated naphthylurea, suramin, is used as a treatment for trypanosome-caused African river blindness. As a competitive inhibitor of heparin, suramin has been described to have anti-viral activity. METHODS: We tested the activity of suramin during CHIKV or Ebola virus infection, using CHIKV and Ebola envelope glycoprotein pseudotyped lentiviral vectors and wild-type CHIKV and Ebola virus. RESULTS: Suramin efficiently inhibited CHIKV and Ebola envelope-mediated gene transfer while vesicular stomatitis virus G protein pseudotyped vectors were only marginally affected. In addition, suramin was able to inhibit wild-type CHIKV and Ebola virus replication in vitro. Inhibition occurred at early time points during CHIKV infection. CONCLUSION: Suramin, also known as Germanin or Bayer-205, is a market-authorized drug, however shows significant side effects, which probably prevents its use as a CHIKV drug, but due to the high lethality of Ebola virus infections, suramin might be valuable against Ebola infections. BioMed Central 2016-08-31 /pmc/articles/PMC5007819/ /pubmed/27581733 http://dx.doi.org/10.1186/s12985-016-0607-2 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Henß, Lisa Beck, Simon Weidner, Tatjana Biedenkopf, Nadine Sliva, Katja Weber, Christopher Becker, Stephan Schnierle, Barbara S. Suramin is a potent inhibitor of Chikungunya and Ebola virus cell entry |
title | Suramin is a potent inhibitor of Chikungunya and Ebola virus cell entry |
title_full | Suramin is a potent inhibitor of Chikungunya and Ebola virus cell entry |
title_fullStr | Suramin is a potent inhibitor of Chikungunya and Ebola virus cell entry |
title_full_unstemmed | Suramin is a potent inhibitor of Chikungunya and Ebola virus cell entry |
title_short | Suramin is a potent inhibitor of Chikungunya and Ebola virus cell entry |
title_sort | suramin is a potent inhibitor of chikungunya and ebola virus cell entry |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007819/ https://www.ncbi.nlm.nih.gov/pubmed/27581733 http://dx.doi.org/10.1186/s12985-016-0607-2 |
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