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KRAS mutation leads to decreased expression of regulator of calcineurin 2, resulting in tumor proliferation in colorectal cancer

KRAS mutations occur in 30–40% of all cases of human colorectal cancer (CRC). However, to date, specific therapeutic agents against KRAS-mutated CRC have not been developed. We previously described the generation of mouse models of colon cancer with and without Kras mutations (CDX2P-G22Cre;Apc(flox/...

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Detalles Bibliográficos
Autores principales:	Niitsu, H, Hinoi, T, Kawaguchi, Y, Sentani, K, Yuge, R, Kitadai, Y, Sotomaru, Y, Adachi, T, Saito, Y, Miguchi, M, Kochi, M, Sada, H, Shimomura, M, Oue, N, Yasui, W, Ohdan, H
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007825/ https://www.ncbi.nlm.nih.gov/pubmed/27526107 http://dx.doi.org/10.1038/oncsis.2016.47

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