Systemic chromosome instability in Shugoshin-1 mice resulted in compromised glutathione pathway, activation of Wnt signaling and defects in immune system in the lung

Mitotic error-mediated chromosome instability (CIN) can lead to aneuploidy, chromothripsis, DNA damage and/or whole chromosome gain/loss. CIN may prompt rapid accumulation of mutations and genomic alterations. Thus, CIN can promote carcinogenesis. This CIN process results from a mutation in certain...

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Detalles Bibliográficos
Autores principales: Yamada, H Y, Kumar, G, Zhang, Y, Rubin, E, Lightfoot, S, Dai, W, Rao, C V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007830/
https://www.ncbi.nlm.nih.gov/pubmed/27526110
http://dx.doi.org/10.1038/oncsis.2016.56

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