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RNF168 cooperates with RNF8 to mediate FOXM1 ubiquitination and degradation in breast cancer epirubicin treatment

The forkhead box M1 (FOXM1) transcription factor has a central role in genotoxic agent response in breast cancer. FOXM1 is regulated at the post-translational level upon DNA damage, but the key mechanism involved remained enigmatic. RNF168 is a ubiquitination E3-ligase involved in DNA damage respons...

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Detalles Bibliográficos
Autores principales:	Kongsema, M, Zona, S, Karunarathna, U, Cabrera, E, Man, E P S, Yao, S, Shibakawa, A, Khoo, U-S, Medema, R H, Freire, R, Lam, E W-F
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007831/ https://www.ncbi.nlm.nih.gov/pubmed/27526106 http://dx.doi.org/10.1038/oncsis.2016.57

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