Multiple mechanisms determine the sensitivity of human-induced pluripotent stem cells to the inducible caspase-9 safety switch

Expression of the inducible caspase-9 (iC9) suicide gene is one of the most appealing safety strategies for cell therapy and has been applied for human-induced pluripotent stem cells (hiPSC) to control the cell fate of hiPSC. iC9 can induce cell death of over 99% of iC9-transduced hiPSC (iC9-hiPSC)...

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Detalles Bibliográficos
Autores principales: Yagyu, Shigeki, Hoyos, Valentina, Del Bufalo, Francesca, Brenner, Malcolm K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008202/
https://www.ncbi.nlm.nih.gov/pubmed/27626039
http://dx.doi.org/10.1038/mtm.2016.3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008202/
https://www.ncbi.nlm.nih.gov/pubmed/27626039
http://dx.doi.org/10.1038/mtm.2016.3

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