High-content molecular profiling of T-cell therapy in oncology

Recent clinical data have revealed the remarkable potential for T-cell-modulating agents to induce potent and durable responses in a subset of cancer patients. In this review, we discuss molecular approaches, platforms, and strategies that enable a broader interrogation of the activity of agents tha...

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Detalles Bibliográficos
Autores principales: Novosiadly, Ruslan, Kalos, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008264/
https://www.ncbi.nlm.nih.gov/pubmed/27626060
http://dx.doi.org/10.1038/mto.2016.9
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author Novosiadly, Ruslan
Kalos, Michael
author_facet Novosiadly, Ruslan
Kalos, Michael
author_sort Novosiadly, Ruslan
collection PubMed
description Recent clinical data have revealed the remarkable potential for T-cell-modulating agents to induce potent and durable responses in a subset of cancer patients. In this review, we discuss molecular approaches, platforms, and strategies that enable a broader interrogation of the activity of agents that modulate the activity of tumor-specific T cells, to more comprehensively understand how and why the agents succeed and fail, as well as examples of data sets generated in clinical trials that have provided important insights into the biological activity of T-cell therapies and that support further rational development of this exciting treatment modality.
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spelling pubmed-50082642016-09-13 High-content molecular profiling of T-cell therapy in oncology Novosiadly, Ruslan Kalos, Michael Mol Ther Oncolytics Review Article Recent clinical data have revealed the remarkable potential for T-cell-modulating agents to induce potent and durable responses in a subset of cancer patients. In this review, we discuss molecular approaches, platforms, and strategies that enable a broader interrogation of the activity of agents that modulate the activity of tumor-specific T cells, to more comprehensively understand how and why the agents succeed and fail, as well as examples of data sets generated in clinical trials that have provided important insights into the biological activity of T-cell therapies and that support further rational development of this exciting treatment modality. Nature Publishing Group 2016-03-30 /pmc/articles/PMC5008264/ /pubmed/27626060 http://dx.doi.org/10.1038/mto.2016.9 Text en Copyright © 2016 Official journal of the American Society of Gene & Cell Therapy http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Review Article
Novosiadly, Ruslan
Kalos, Michael
High-content molecular profiling of T-cell therapy in oncology
title High-content molecular profiling of T-cell therapy in oncology
title_full High-content molecular profiling of T-cell therapy in oncology
title_fullStr High-content molecular profiling of T-cell therapy in oncology
title_full_unstemmed High-content molecular profiling of T-cell therapy in oncology
title_short High-content molecular profiling of T-cell therapy in oncology
title_sort high-content molecular profiling of t-cell therapy in oncology
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008264/
https://www.ncbi.nlm.nih.gov/pubmed/27626060
http://dx.doi.org/10.1038/mto.2016.9
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AT kalosmichael highcontentmolecularprofilingoftcelltherapyinoncology

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