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PI3K/Akt promotes feedforward mTORC2 activation through IKKα

The ser-thr Akt plays a critical role in the regulation of cell survival, cell growth and proliferation, as well as energy metabolism and is dysregulated in many cancers. The regulation of Akt activity depends on the phosphorylation at two sites: (i) Thr308 in the activation loop by phosphoinositide...

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Detalles Bibliográficos
Autores principales:	Dan, Han C., Antonia, Ricardo J., Baldwin, Albert S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Priority Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008269/ https://www.ncbi.nlm.nih.gov/pubmed/27027448 http://dx.doi.org/10.18632/oncotarget.8383

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