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Autophagy-associated immune responses and cancer immunotherapy

Autophagy is an evolutionarily conserved catabolic process by which cellular components are sequestered into a double-membrane vesicle and delivered to the lysosome for terminal degradation and recycling. Accumulating evidence suggests that autophagy plays a critical role in cell survival, senescenc...

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Autores principales: Pan, Hongming, Chen, Liuxi, Xu, Yinghua, Han, Weidong, Lou, Fang, Fei, Weiqiang, Liu, Shuiping, Jing, Zhao, Sui, Xinbing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008281/
https://www.ncbi.nlm.nih.gov/pubmed/26788909
http://dx.doi.org/10.18632/oncotarget.6908
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author Pan, Hongming
Chen, Liuxi
Xu, Yinghua
Han, Weidong
Lou, Fang
Fei, Weiqiang
Liu, Shuiping
Jing, Zhao
Sui, Xinbing
author_facet Pan, Hongming
Chen, Liuxi
Xu, Yinghua
Han, Weidong
Lou, Fang
Fei, Weiqiang
Liu, Shuiping
Jing, Zhao
Sui, Xinbing
author_sort Pan, Hongming
collection PubMed
description Autophagy is an evolutionarily conserved catabolic process by which cellular components are sequestered into a double-membrane vesicle and delivered to the lysosome for terminal degradation and recycling. Accumulating evidence suggests that autophagy plays a critical role in cell survival, senescence and homeostasis, and its dysregulation is associated with a variety of diseases including cancer, cardiovascular disease, neurodegeneration. Recent studies show that autophagy is also an important regulator of cell immune response. However, the mechanism by which autophagy regulates tumor immune responses remains elusive. In this review, we will describe the role of autophagy in immune regulation and summarize the possible molecular mechanisms that are currently well documented in the ability of autophagy to control cell immune response. In addition, the scientific and clinical hurdles regarding the potential role of autophagy in cancer immunotherapy will be discussed.
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spelling pubmed-50082812016-09-12 Autophagy-associated immune responses and cancer immunotherapy Pan, Hongming Chen, Liuxi Xu, Yinghua Han, Weidong Lou, Fang Fei, Weiqiang Liu, Shuiping Jing, Zhao Sui, Xinbing Oncotarget Review Autophagy is an evolutionarily conserved catabolic process by which cellular components are sequestered into a double-membrane vesicle and delivered to the lysosome for terminal degradation and recycling. Accumulating evidence suggests that autophagy plays a critical role in cell survival, senescence and homeostasis, and its dysregulation is associated with a variety of diseases including cancer, cardiovascular disease, neurodegeneration. Recent studies show that autophagy is also an important regulator of cell immune response. However, the mechanism by which autophagy regulates tumor immune responses remains elusive. In this review, we will describe the role of autophagy in immune regulation and summarize the possible molecular mechanisms that are currently well documented in the ability of autophagy to control cell immune response. In addition, the scientific and clinical hurdles regarding the potential role of autophagy in cancer immunotherapy will be discussed. Impact Journals LLC 2016-01-13 /pmc/articles/PMC5008281/ /pubmed/26788909 http://dx.doi.org/10.18632/oncotarget.6908 Text en Copyright: © 2016 Pan et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review
Pan, Hongming
Chen, Liuxi
Xu, Yinghua
Han, Weidong
Lou, Fang
Fei, Weiqiang
Liu, Shuiping
Jing, Zhao
Sui, Xinbing
Autophagy-associated immune responses and cancer immunotherapy
title Autophagy-associated immune responses and cancer immunotherapy
title_full Autophagy-associated immune responses and cancer immunotherapy
title_fullStr Autophagy-associated immune responses and cancer immunotherapy
title_full_unstemmed Autophagy-associated immune responses and cancer immunotherapy
title_short Autophagy-associated immune responses and cancer immunotherapy
title_sort autophagy-associated immune responses and cancer immunotherapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008281/
https://www.ncbi.nlm.nih.gov/pubmed/26788909
http://dx.doi.org/10.18632/oncotarget.6908
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