4EGI-1 induces apoptosis and enhances radiotherapy sensitivity in nasopharyngeal carcinoma cells via DR5 induction on 4E-BP1 dephosphorylation

The eIF4F complex regulated by a various group of eIF4E-binding proteins (4E-BPs) can initial the protein synthesis. Small molecule compound 4EGI-1, an inhibitor of the cap-dependent translation initiation through disturbing the interaction between eIF4E and eIF4G which are main elements of the eIF4...

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Detalles Bibliográficos
Autores principales: Wang, Weiyuan, Li, Jiao, Wen, Qiuyuan, Luo, Jiadi, Chu, Shuzhou, Chen, Lingjiao, Qing, Zhenzhen, Xie, Guiyuan, Xu, Lina, Alnemah, Mohannad Ma, Li, Meirong, Fan, Songqing, Zhang, Hongbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008318/
https://www.ncbi.nlm.nih.gov/pubmed/26942880
http://dx.doi.org/10.18632/oncotarget.7824

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