Pin1 is required for sustained B cell proliferation upon oncogenic activation of Myc

The c-myc proto-oncogene is activated by translocation in Burkitt's lymphoma and substitutions in codon 58 stabilize the Myc protein or augment its oncogenic potential. In wild-type Myc, phosphorylation of Ser 62 and Thr 58 provides a landing pad for the peptidyl prolyl-isomerase Pin1, which in...

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Detalles Bibliográficos
Autores principales: D'Artista, Luana, Bisso, Andrea, Piontini, Andrea, Doni, Mirko, Verrecchia, Alessandro, Kress, Theresia R., Morelli, Marco J., Del Sal, Giannino, Amati, Bruno, Campaner, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008323/
https://www.ncbi.nlm.nih.gov/pubmed/26943576
http://dx.doi.org/10.18632/oncotarget.7846

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008323/
https://www.ncbi.nlm.nih.gov/pubmed/26943576
http://dx.doi.org/10.18632/oncotarget.7846

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