Increased PTP1B expression and phosphatase activity in colorectal cancer results in a more invasive phenotype and worse patient outcome

Cell signaling is dependent on the balance between phosphorylation of proteins by kinases and dephosphorylation by phosphatases. This balance if often disrupted in colorectal cancer (CRC), leading to increased cell proliferation and invasion. For many years research has focused on the role of kinase...

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Detalles Bibliográficos
Autores principales: Hoekstra, Elmer, Das, Asha M., Swets, Marloes, Cao, Wanlu, van der Woude, C. Janneke, Bruno, Marco J., Peppelenbosch, Maikel P., Kuppen, Peter J.K., ten Hagen, Timo L.M., Fuhler, Gwenny M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008334/
https://www.ncbi.nlm.nih.gov/pubmed/26942883
http://dx.doi.org/10.18632/oncotarget.7829

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