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Short- and long-term outcomes in onco-hematological patients admitted to the intensive care unit with classic factors of poor prognosis
Although the overall mortality of patients admitted to intensive care units (ICU) with hematological malignancy has decreased over the years, some groups of patients still have low survival rates. We performed a monocentric retrospective study including all patients with hematological malignancy in...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008370/ https://www.ncbi.nlm.nih.gov/pubmed/26968953 http://dx.doi.org/10.18632/oncotarget.7986 |
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author | Faucher, Etienne Cour, Martin Jahandiez, Vincent Grateau, Adeline Baudry, Thomas Hernu, Romain Simon, Marie Robert, Jean-michel Michallet, Mauricette Argaud, Laurent |
author_facet | Faucher, Etienne Cour, Martin Jahandiez, Vincent Grateau, Adeline Baudry, Thomas Hernu, Romain Simon, Marie Robert, Jean-michel Michallet, Mauricette Argaud, Laurent |
author_sort | Faucher, Etienne |
collection | PubMed |
description | Although the overall mortality of patients admitted to intensive care units (ICU) with hematological malignancy has decreased over the years, some groups of patients still have low survival rates. We performed a monocentric retrospective study including all patients with hematological malignancy in a ten-year period, to identify factors related to the outcome for the whole cohort and for patients with allogeneic hematopoietic stem cell transplantation (HSCT), neutropenia, or those requiring invasive mechanical ventilation (IMV). A total of 418 patients with acute leukemia (n=239; 57%), myeloma (n=69; 17%), and lymphoma (n=53; 13%) were studied. Day-28 and 1-year mortality were 49% and 72%, respectively. The type of disease was not associated with outcome. The disease status was independentlty associated with 1-year mortality only. Independent predictors of day-28 mortality were IMV, renal replacement therapy (RRT), and performance status. For allogeneic HSCT recipients (n=116), neutropenic patients (n=124) and patients requiring IMV (n=196), day-28 and 1-year mortality were 52%, 54%, 74% and 81%, 78%, 87%, respectively. Multivariate analysis showed that IMV and RRT for allogeneic HSCT recipients, performance status and IMV for neutropenic patients, and RRT for patients requiring IMV were independently associated with short-term mortality (p<0.05). These results suggest that IMV is the strongest predictor of mortality in hematological patients admitted to ICUs, whereas allogeneic HSCT and neutropenia do not worsen their short-term outcome. |
format | Online Article Text |
id | pubmed-5008370 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-50083702016-09-12 Short- and long-term outcomes in onco-hematological patients admitted to the intensive care unit with classic factors of poor prognosis Faucher, Etienne Cour, Martin Jahandiez, Vincent Grateau, Adeline Baudry, Thomas Hernu, Romain Simon, Marie Robert, Jean-michel Michallet, Mauricette Argaud, Laurent Oncotarget Research Paper Although the overall mortality of patients admitted to intensive care units (ICU) with hematological malignancy has decreased over the years, some groups of patients still have low survival rates. We performed a monocentric retrospective study including all patients with hematological malignancy in a ten-year period, to identify factors related to the outcome for the whole cohort and for patients with allogeneic hematopoietic stem cell transplantation (HSCT), neutropenia, or those requiring invasive mechanical ventilation (IMV). A total of 418 patients with acute leukemia (n=239; 57%), myeloma (n=69; 17%), and lymphoma (n=53; 13%) were studied. Day-28 and 1-year mortality were 49% and 72%, respectively. The type of disease was not associated with outcome. The disease status was independentlty associated with 1-year mortality only. Independent predictors of day-28 mortality were IMV, renal replacement therapy (RRT), and performance status. For allogeneic HSCT recipients (n=116), neutropenic patients (n=124) and patients requiring IMV (n=196), day-28 and 1-year mortality were 52%, 54%, 74% and 81%, 78%, 87%, respectively. Multivariate analysis showed that IMV and RRT for allogeneic HSCT recipients, performance status and IMV for neutropenic patients, and RRT for patients requiring IMV were independently associated with short-term mortality (p<0.05). These results suggest that IMV is the strongest predictor of mortality in hematological patients admitted to ICUs, whereas allogeneic HSCT and neutropenia do not worsen their short-term outcome. Impact Journals LLC 2016-03-08 /pmc/articles/PMC5008370/ /pubmed/26968953 http://dx.doi.org/10.18632/oncotarget.7986 Text en Copyright: © 2016 Faucher et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Faucher, Etienne Cour, Martin Jahandiez, Vincent Grateau, Adeline Baudry, Thomas Hernu, Romain Simon, Marie Robert, Jean-michel Michallet, Mauricette Argaud, Laurent Short- and long-term outcomes in onco-hematological patients admitted to the intensive care unit with classic factors of poor prognosis |
title | Short- and long-term outcomes in onco-hematological patients admitted to the intensive care unit with classic factors of poor prognosis |
title_full | Short- and long-term outcomes in onco-hematological patients admitted to the intensive care unit with classic factors of poor prognosis |
title_fullStr | Short- and long-term outcomes in onco-hematological patients admitted to the intensive care unit with classic factors of poor prognosis |
title_full_unstemmed | Short- and long-term outcomes in onco-hematological patients admitted to the intensive care unit with classic factors of poor prognosis |
title_short | Short- and long-term outcomes in onco-hematological patients admitted to the intensive care unit with classic factors of poor prognosis |
title_sort | short- and long-term outcomes in onco-hematological patients admitted to the intensive care unit with classic factors of poor prognosis |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008370/ https://www.ncbi.nlm.nih.gov/pubmed/26968953 http://dx.doi.org/10.18632/oncotarget.7986 |
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