Regulation of limited N-terminal proteolysis of APE1 in tumor via acetylation and its role in cell proliferation

Mammalian apurinic/apyrimidinic (AP) endonuclease 1 (APE1), a ubiquitous and multifunctional protein, plays an essential role in the repair of both endogenous and drug-induced DNA damages in the genome. Unlike its E.coli counterpart Xth, mammalian APE1 has a unique N-terminal domain and possesses bo...

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Detalles Bibliográficos
Autores principales: Bhakat, Kishor K., Sengupta, Shiladitya, Adeniyi, Victor F., Roychoudhury, Shrabasti, Nath, Somsubhra, Bellot, Larry J., Feng, Dan, Mantha, Anil K., Sinha, Mala, Qiu, Suimin, Luxon, Bruce A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008384/
https://www.ncbi.nlm.nih.gov/pubmed/26981776
http://dx.doi.org/10.18632/oncotarget.8026

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