DDX3 enhances oncogenic KRAS-induced tumor invasion in colorectal cancer via the β-catenin/ZEB1 axis

DDX3 plays a dual role in colorectal cancer; however, the role and underlying mechanism of DDX3 in colorectal tumorigenesis remains unclear. Here, we provide evidence that DDX3 enhances oncogenic KRAS transcription via an increase in SP1 binding to its promoter. Accelerating oncogenic KRAS expressio...

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Detalles Bibliográficos
Autores principales: Wu, De-Wei, Lin, Po-Lin, Cheng, Ya-Wen, Huang, Chi-Chou, Wang, Lee, Lee, Huei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008392/
https://www.ncbi.nlm.nih.gov/pubmed/27007150
http://dx.doi.org/10.18632/oncotarget.8143

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008392/
https://www.ncbi.nlm.nih.gov/pubmed/27007150
http://dx.doi.org/10.18632/oncotarget.8143

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