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LMO1 gene polymorphisms contribute to decreased neuroblastoma susceptibility in a Southern Chinese population

Neuroblastoma is one of the most commonly diagnosed extracranial solid tumors in infancy; however, the etiology of neuroblastoma remains largely unknown. Previous genome-wide association study (GWAS) indicated that several common genetic variations (rs110419 A > G, rs4758051 G > A, rs10840002...

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Autores principales: He, Jing, Zhong, Wei, Zeng, Jixiao, Zhu, Jinhong, Zhang, Ruizhong, Wang, Fenghua, Yang, Tianyou, Zou, Yan, Xia, Huimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008399/
https://www.ncbi.nlm.nih.gov/pubmed/27009839
http://dx.doi.org/10.18632/oncotarget.8178
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author He, Jing
Zhong, Wei
Zeng, Jixiao
Zhu, Jinhong
Zhang, Ruizhong
Wang, Fenghua
Yang, Tianyou
Zou, Yan
Xia, Huimin
author_facet He, Jing
Zhong, Wei
Zeng, Jixiao
Zhu, Jinhong
Zhang, Ruizhong
Wang, Fenghua
Yang, Tianyou
Zou, Yan
Xia, Huimin
author_sort He, Jing
collection PubMed
description Neuroblastoma is one of the most commonly diagnosed extracranial solid tumors in infancy; however, the etiology of neuroblastoma remains largely unknown. Previous genome-wide association study (GWAS) indicated that several common genetic variations (rs110419 A > G, rs4758051 G > A, rs10840002 A > G and rs204938 A > G) in the LIM domain only 1 (LMO1) gene were associated with neuroblastoma susceptibility. The aim of this study was to evaluate the correlation between the four GWAS-identified LMO1 gene polymorphisms and neuroblastoma risk in a Southern Chinese population. We genotyped the four polymorphisms in 256 neuroblastoma cases and 531 controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to evaluate the strength of the associations. False-positive report probability was calculated for all significant findings. We found that the rs110419 A > G polymorphism was associated with a significantly decreased neuroblastoma risk (AG vs. AA: adjusted OR = 0.65, 95% CI = 0.47–0.91; GG vs. AA: adjusted OR = 0.58, 95% CI = 0.36–0.91; AG/GG vs. AA: adjusted OR = 0.63, 95% CI = 0.46–0.86), and the protective effect was more predominant in children of age > 18 months, males, subgroups with tumor in adrenal gland and mediastinum, and patients in clinical stages III/IV. These results suggested that LMO1 gene rs110419 A > G polymorphism may contribute to protection against neuroblastoma. Our findings call for further validation studies with larger sample size.
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spelling pubmed-50083992016-09-12 LMO1 gene polymorphisms contribute to decreased neuroblastoma susceptibility in a Southern Chinese population He, Jing Zhong, Wei Zeng, Jixiao Zhu, Jinhong Zhang, Ruizhong Wang, Fenghua Yang, Tianyou Zou, Yan Xia, Huimin Oncotarget Research Paper Neuroblastoma is one of the most commonly diagnosed extracranial solid tumors in infancy; however, the etiology of neuroblastoma remains largely unknown. Previous genome-wide association study (GWAS) indicated that several common genetic variations (rs110419 A > G, rs4758051 G > A, rs10840002 A > G and rs204938 A > G) in the LIM domain only 1 (LMO1) gene were associated with neuroblastoma susceptibility. The aim of this study was to evaluate the correlation between the four GWAS-identified LMO1 gene polymorphisms and neuroblastoma risk in a Southern Chinese population. We genotyped the four polymorphisms in 256 neuroblastoma cases and 531 controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to evaluate the strength of the associations. False-positive report probability was calculated for all significant findings. We found that the rs110419 A > G polymorphism was associated with a significantly decreased neuroblastoma risk (AG vs. AA: adjusted OR = 0.65, 95% CI = 0.47–0.91; GG vs. AA: adjusted OR = 0.58, 95% CI = 0.36–0.91; AG/GG vs. AA: adjusted OR = 0.63, 95% CI = 0.46–0.86), and the protective effect was more predominant in children of age > 18 months, males, subgroups with tumor in adrenal gland and mediastinum, and patients in clinical stages III/IV. These results suggested that LMO1 gene rs110419 A > G polymorphism may contribute to protection against neuroblastoma. Our findings call for further validation studies with larger sample size. Impact Journals LLC 2016-03-18 /pmc/articles/PMC5008399/ /pubmed/27009839 http://dx.doi.org/10.18632/oncotarget.8178 Text en Copyright: © 2016 He et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
He, Jing
Zhong, Wei
Zeng, Jixiao
Zhu, Jinhong
Zhang, Ruizhong
Wang, Fenghua
Yang, Tianyou
Zou, Yan
Xia, Huimin
LMO1 gene polymorphisms contribute to decreased neuroblastoma susceptibility in a Southern Chinese population
title LMO1 gene polymorphisms contribute to decreased neuroblastoma susceptibility in a Southern Chinese population
title_full LMO1 gene polymorphisms contribute to decreased neuroblastoma susceptibility in a Southern Chinese population
title_fullStr LMO1 gene polymorphisms contribute to decreased neuroblastoma susceptibility in a Southern Chinese population
title_full_unstemmed LMO1 gene polymorphisms contribute to decreased neuroblastoma susceptibility in a Southern Chinese population
title_short LMO1 gene polymorphisms contribute to decreased neuroblastoma susceptibility in a Southern Chinese population
title_sort lmo1 gene polymorphisms contribute to decreased neuroblastoma susceptibility in a southern chinese population
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008399/
https://www.ncbi.nlm.nih.gov/pubmed/27009839
http://dx.doi.org/10.18632/oncotarget.8178
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