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Association Between NAT2 Polymorphisms and Lung Cancer Susceptibility
To further investigate the association between NAT2 polymorphisms and lung cancer susceptibility. In terms of phenotypes, we investigated the acetylator status of NAT2 polymorphisms associated with lung cancer risk. Additionally, in view of genotypes, we mainly analyzed 5 single nucleotide polymorph...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008471/ https://www.ncbi.nlm.nih.gov/pubmed/26656326 http://dx.doi.org/10.1097/MD.0000000000001947 |
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author | Liu, Chang Cui, Wei Cong, Lin Wang, Li Ruan, Xinjian Jia, Jia Liu, Yanfang Jia, Xiaoyan Zhang, Xia |
author_facet | Liu, Chang Cui, Wei Cong, Lin Wang, Li Ruan, Xinjian Jia, Jia Liu, Yanfang Jia, Xiaoyan Zhang, Xia |
author_sort | Liu, Chang |
collection | PubMed |
description | To further investigate the association between NAT2 polymorphisms and lung cancer susceptibility. In terms of phenotypes, we investigated the acetylator status of NAT2 polymorphisms associated with lung cancer risk. Additionally, in view of genotypes, we mainly analyzed 5 single nucleotide polymorphisms (SNPs) in NAT2 gene, namely C282T, A803G, C481T, G590A, and G857A. Twenty-six eligible studies were included in our meta-analysis by searching PubMed, Embase, and CNKI databases. We used odds ratios (ORs) with corresponding 95% confidence intervals (CIs) to evaluate the susceptibility to lung cancer associated with NAT2 polymorphisms. Overall, based on phenotypes, the pooled ORs showed no significant association between NAT2 polymorphisms and lung cancer susceptibility. In the subgroup analyses by ethnicity and source of control, there was still no significant association. In terms of genotypes, overall, no obvious relationship was observed between NAT2 polymorphisms and lung cancer risk. But increased risk of lung cancer was found in association with NAT2 C282T polymorphism (TT vs. CC + TC: OR = 1.58, 95% CI = 1.11–2.25). Our meta-analysis demonstrates that TT genotype in NAT2 C282T polymorphism may be a risk factor for lung cancer susceptibility. Additionally, the acetylator status of 5 SNPs in NAT2 gene may not be associated with lung cancer risk. |
format | Online Article Text |
id | pubmed-5008471 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-50084712016-09-09 Association Between NAT2 Polymorphisms and Lung Cancer Susceptibility Liu, Chang Cui, Wei Cong, Lin Wang, Li Ruan, Xinjian Jia, Jia Liu, Yanfang Jia, Xiaoyan Zhang, Xia Medicine (Baltimore) 6700 To further investigate the association between NAT2 polymorphisms and lung cancer susceptibility. In terms of phenotypes, we investigated the acetylator status of NAT2 polymorphisms associated with lung cancer risk. Additionally, in view of genotypes, we mainly analyzed 5 single nucleotide polymorphisms (SNPs) in NAT2 gene, namely C282T, A803G, C481T, G590A, and G857A. Twenty-six eligible studies were included in our meta-analysis by searching PubMed, Embase, and CNKI databases. We used odds ratios (ORs) with corresponding 95% confidence intervals (CIs) to evaluate the susceptibility to lung cancer associated with NAT2 polymorphisms. Overall, based on phenotypes, the pooled ORs showed no significant association between NAT2 polymorphisms and lung cancer susceptibility. In the subgroup analyses by ethnicity and source of control, there was still no significant association. In terms of genotypes, overall, no obvious relationship was observed between NAT2 polymorphisms and lung cancer risk. But increased risk of lung cancer was found in association with NAT2 C282T polymorphism (TT vs. CC + TC: OR = 1.58, 95% CI = 1.11–2.25). Our meta-analysis demonstrates that TT genotype in NAT2 C282T polymorphism may be a risk factor for lung cancer susceptibility. Additionally, the acetylator status of 5 SNPs in NAT2 gene may not be associated with lung cancer risk. Wolters Kluwer Health 2015-12-11 /pmc/articles/PMC5008471/ /pubmed/26656326 http://dx.doi.org/10.1097/MD.0000000000001947 Text en Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 |
spellingShingle | 6700 Liu, Chang Cui, Wei Cong, Lin Wang, Li Ruan, Xinjian Jia, Jia Liu, Yanfang Jia, Xiaoyan Zhang, Xia Association Between NAT2 Polymorphisms and Lung Cancer Susceptibility |
title | Association Between NAT2 Polymorphisms and Lung Cancer Susceptibility |
title_full | Association Between NAT2 Polymorphisms and Lung Cancer Susceptibility |
title_fullStr | Association Between NAT2 Polymorphisms and Lung Cancer Susceptibility |
title_full_unstemmed | Association Between NAT2 Polymorphisms and Lung Cancer Susceptibility |
title_short | Association Between NAT2 Polymorphisms and Lung Cancer Susceptibility |
title_sort | association between nat2 polymorphisms and lung cancer susceptibility |
topic | 6700 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008471/ https://www.ncbi.nlm.nih.gov/pubmed/26656326 http://dx.doi.org/10.1097/MD.0000000000001947 |
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