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Comparison of childhood thyroid cancer prevalence among 3 areas based on external radiation dose after the Fukushima Daiichi nuclear power plant accident: The Fukushima health management survey
The 2011 Great East Japan Earthquake led to a subsequent nuclear accident at the Fukushima Daiichi Nuclear Power Plant. In its wake, we sought to examine the association between external radiation dose and thyroid cancer in Fukushima Prefecture. We applied a cross-sectional study design with 300,476...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008539/ https://www.ncbi.nlm.nih.gov/pubmed/27583855 http://dx.doi.org/10.1097/MD.0000000000004472 |
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author | Ohira, Tetsuya Takahashi, Hideto Yasumura, Seiji Ohtsuru, Akira Midorikawa, Sanae Suzuki, Satoru Fukushima, Toshihiko Shimura, Hiroki Ishikawa, Tetsuo Sakai, Akira Yamashita, Shunichi Tanigawa, Koichi Ohto, Hitoshi Abe, Masafumi Suzuki, Shinichi |
author_facet | Ohira, Tetsuya Takahashi, Hideto Yasumura, Seiji Ohtsuru, Akira Midorikawa, Sanae Suzuki, Satoru Fukushima, Toshihiko Shimura, Hiroki Ishikawa, Tetsuo Sakai, Akira Yamashita, Shunichi Tanigawa, Koichi Ohto, Hitoshi Abe, Masafumi Suzuki, Shinichi |
author_sort | Ohira, Tetsuya |
collection | PubMed |
description | The 2011 Great East Japan Earthquake led to a subsequent nuclear accident at the Fukushima Daiichi Nuclear Power Plant. In its wake, we sought to examine the association between external radiation dose and thyroid cancer in Fukushima Prefecture. We applied a cross-sectional study design with 300,476 participants aged 18 years and younger who underwent thyroid examinations between October 2011 and June 2015. Areas within Fukushima Prefecture were divided into three groups based on individual external doses (≥1% of 5 mSv, <99% of 1 mSv/y, and the other). The odds ratios (ORs) and 95% confidence intervals of thyroid cancer for all areas, with the lowest dose area as reference, were calculated using logistic regression models adjusted for age and sex. Furthermore, the ORs of thyroid cancer for individual external doses of 1 mSv or more and 2 mSv or more, with the external dose less than 1 mSv as reference, were calculated. Prevalence of thyroid cancer for the location groups were 48/100,000 for the highest dose area, 36/100,000 for the middle dose area, and 41/100,000 for the lowest dose area. Compared with the lowest dose area, age-, and sex-adjusted ORs (95% confidence intervals) for the highest-dose and middle-dose areas were 1.49 (0.36–6.23) and 1.00 (0.67–1.50), respectively. The duration between accident and thyroid examination was not associated with thyroid cancer prevalence. There were no significant associations between individual external doses and prevalence of thyroid cancer. External radiation dose was not associated with thyroid cancer prevalence among Fukushima children within the first 4 years after the nuclear accident. |
format | Online Article Text |
id | pubmed-5008539 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-50085392016-09-10 Comparison of childhood thyroid cancer prevalence among 3 areas based on external radiation dose after the Fukushima Daiichi nuclear power plant accident: The Fukushima health management survey Ohira, Tetsuya Takahashi, Hideto Yasumura, Seiji Ohtsuru, Akira Midorikawa, Sanae Suzuki, Satoru Fukushima, Toshihiko Shimura, Hiroki Ishikawa, Tetsuo Sakai, Akira Yamashita, Shunichi Tanigawa, Koichi Ohto, Hitoshi Abe, Masafumi Suzuki, Shinichi Medicine (Baltimore) 4400 The 2011 Great East Japan Earthquake led to a subsequent nuclear accident at the Fukushima Daiichi Nuclear Power Plant. In its wake, we sought to examine the association between external radiation dose and thyroid cancer in Fukushima Prefecture. We applied a cross-sectional study design with 300,476 participants aged 18 years and younger who underwent thyroid examinations between October 2011 and June 2015. Areas within Fukushima Prefecture were divided into three groups based on individual external doses (≥1% of 5 mSv, <99% of 1 mSv/y, and the other). The odds ratios (ORs) and 95% confidence intervals of thyroid cancer for all areas, with the lowest dose area as reference, were calculated using logistic regression models adjusted for age and sex. Furthermore, the ORs of thyroid cancer for individual external doses of 1 mSv or more and 2 mSv or more, with the external dose less than 1 mSv as reference, were calculated. Prevalence of thyroid cancer for the location groups were 48/100,000 for the highest dose area, 36/100,000 for the middle dose area, and 41/100,000 for the lowest dose area. Compared with the lowest dose area, age-, and sex-adjusted ORs (95% confidence intervals) for the highest-dose and middle-dose areas were 1.49 (0.36–6.23) and 1.00 (0.67–1.50), respectively. The duration between accident and thyroid examination was not associated with thyroid cancer prevalence. There were no significant associations between individual external doses and prevalence of thyroid cancer. External radiation dose was not associated with thyroid cancer prevalence among Fukushima children within the first 4 years after the nuclear accident. Wolters Kluwer Health 2016-09-02 /pmc/articles/PMC5008539/ /pubmed/27583855 http://dx.doi.org/10.1097/MD.0000000000004472 Text en Copyright © 2016 the Author(s). Published by Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially. http://creativecommons.org/licenses/by-nc/4.0 |
spellingShingle | 4400 Ohira, Tetsuya Takahashi, Hideto Yasumura, Seiji Ohtsuru, Akira Midorikawa, Sanae Suzuki, Satoru Fukushima, Toshihiko Shimura, Hiroki Ishikawa, Tetsuo Sakai, Akira Yamashita, Shunichi Tanigawa, Koichi Ohto, Hitoshi Abe, Masafumi Suzuki, Shinichi Comparison of childhood thyroid cancer prevalence among 3 areas based on external radiation dose after the Fukushima Daiichi nuclear power plant accident: The Fukushima health management survey |
title | Comparison of childhood thyroid cancer prevalence among 3 areas based on external radiation dose after the Fukushima Daiichi nuclear power plant accident: The Fukushima health management survey |
title_full | Comparison of childhood thyroid cancer prevalence among 3 areas based on external radiation dose after the Fukushima Daiichi nuclear power plant accident: The Fukushima health management survey |
title_fullStr | Comparison of childhood thyroid cancer prevalence among 3 areas based on external radiation dose after the Fukushima Daiichi nuclear power plant accident: The Fukushima health management survey |
title_full_unstemmed | Comparison of childhood thyroid cancer prevalence among 3 areas based on external radiation dose after the Fukushima Daiichi nuclear power plant accident: The Fukushima health management survey |
title_short | Comparison of childhood thyroid cancer prevalence among 3 areas based on external radiation dose after the Fukushima Daiichi nuclear power plant accident: The Fukushima health management survey |
title_sort | comparison of childhood thyroid cancer prevalence among 3 areas based on external radiation dose after the fukushima daiichi nuclear power plant accident: the fukushima health management survey |
topic | 4400 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008539/ https://www.ncbi.nlm.nih.gov/pubmed/27583855 http://dx.doi.org/10.1097/MD.0000000000004472 |
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