Direct and Auger Electron-Induced, Single- and Double-Strand Breaks on Plasmid DNA Caused by (99m)Tc-Labeled Pyrene Derivatives and the Effect of Bonding Distance

It is evident that (99m)Tc causes radical-mediated DNA damage due to Auger electrons, which were emitted simultaneously with the known γ-emission of (99m)Tc. We have synthesized a series of new (99m)Tc-labeled pyrene derivatives with varied distances between the pyrene moiety and the radionuclide. T...

Descripción completa

Detalles Bibliográficos
Autores principales: Reissig, Falco, Mamat, Constantin, Steinbach, Joerg, Pietzsch, Hans-Juergen, Freudenberg, Robert, Navarro-Retamal, Carlos, Caballero, Julio, Kotzerke, Joerg, Wunderlich, Gerd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008623/
https://www.ncbi.nlm.nih.gov/pubmed/27583677
http://dx.doi.org/10.1371/journal.pone.0161973

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008623/
https://www.ncbi.nlm.nih.gov/pubmed/27583677
http://dx.doi.org/10.1371/journal.pone.0161973

Ejemplares similares