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Direct and Auger Electron-Induced, Single- and Double-Strand Breaks on Plasmid DNA Caused by (99m)Tc-Labeled Pyrene Derivatives and the Effect of Bonding Distance
It is evident that (99m)Tc causes radical-mediated DNA damage due to Auger electrons, which were emitted simultaneously with the known γ-emission of (99m)Tc. We have synthesized a series of new (99m)Tc-labeled pyrene derivatives with varied distances between the pyrene moiety and the radionuclide. T...
Autores principales: | Reissig, Falco, Mamat, Constantin, Steinbach, Joerg, Pietzsch, Hans-Juergen, Freudenberg, Robert, Navarro-Retamal, Carlos, Caballero, Julio, Kotzerke, Joerg, Wunderlich, Gerd |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008623/ https://www.ncbi.nlm.nih.gov/pubmed/27583677 http://dx.doi.org/10.1371/journal.pone.0161973 |
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