Structural Insight into the Critical Role of the N-Terminal Region in the Catalytic Activity of Dual-Specificity Phosphatase 26

Human dual-specificity phosphatase 26 (DUSP26) is a novel target for anticancer therapy because its dephosphorylation of the p53 tumor suppressor regulates the apoptosis of cancer cells. DUSP26 inhibition results in neuroblastoma cell cytotoxicity through p53-mediated apoptosis. Despite the previous...

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Detalles Bibliográficos
Autores principales: Won, Eun-Young, Lee, Sang-Ok, Lee, Dong-Hwa, Lee, Daeyoup, Bae, Kwang-Hee, Lee, Sang Chul, Kim, Seung Jun, Chi, Seung-Wook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008780/
https://www.ncbi.nlm.nih.gov/pubmed/27583453
http://dx.doi.org/10.1371/journal.pone.0162115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008780/
https://www.ncbi.nlm.nih.gov/pubmed/27583453
http://dx.doi.org/10.1371/journal.pone.0162115

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