Cargando…

Structural Insight into the Critical Role of the N-Terminal Region in the Catalytic Activity of Dual-Specificity Phosphatase 26

Human dual-specificity phosphatase 26 (DUSP26) is a novel target for anticancer therapy because its dephosphorylation of the p53 tumor suppressor regulates the apoptosis of cancer cells. DUSP26 inhibition results in neuroblastoma cell cytotoxicity through p53-mediated apoptosis. Despite the previous...

Descripción completa

Detalles Bibliográficos
Autores principales:	Won, Eun-Young, Lee, Sang-Ok, Lee, Dong-Hwa, Lee, Daeyoup, Bae, Kwang-Hee, Lee, Sang Chul, Kim, Seung Jun, Chi, Seung-Wook
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008780/ https://www.ncbi.nlm.nih.gov/pubmed/27583453 http://dx.doi.org/10.1371/journal.pone.0162115

Ejemplares similares

Dual-Specificity Phosphatase 10 Controls Brown Adipocyte Differentiation by Modulating the Phosphorylation of P38 Mitogen-Activated Protein Kinase
por: Choi, Hye-Ryung, et al.
Publicado: (2013)

Involvement of protein tyrosine phosphatases in adipogenesis: New anti-obesity targets?
por: Bae, Kwang-Hee, et al.
Publicado: (2012)

Gender-Specific Metabolomic Profiling of Obesity in Leptin-Deficient ob/ob Mice by (1)H NMR Spectroscopy
por: Won, Eun-Young, et al.
Publicado: (2013)

Association between Serum Alkaline Phosphatase Level and Cerebral Small Vessel Disease
por: Lee, Han-Bin, et al.
Publicado: (2015)

Suppression of Dual Specificity Phosphatase I Expression Inhibits Hepatitis C Virus Replication
por: Choi, Jung Eun, et al.
Publicado: (2015)

Roles of Protein Histidine Phosphatase 1 (PHPT1) in Brown Adipocyte Differentiation
por: Kang, Joo Ae Kang Hyun Sup, et al.
Publicado: (2020)

Potentiation of the anticancer effects of everolimus using a dual mTORC1/2 inhibitor in hepatocellular carcinoma cells
por: Kim, Jong-Ok, et al.
Publicado: (2016)

The Latest Insights into Adipokines in Diabetes
por: Kim, Won Kon, et al.
Publicado: (2019)

Protein tyrosine phosphatase profiling studies during brown adipogenic differentiation of mouse primary brown preadipocytes
por: Choi, Hye-Ryung, et al.
Publicado: (2013)

Genetic Screening of GJB2 and SLC26A4 in Korean Cochlear Implantees: Experience of Soree Ear Clinic
por: Shin, Joong-Wook, et al.
Publicado: (2012)

RNA‐seq profiling of tubulointerstitial tissue reveals a potential therapeutic role of dual anti‐phosphatase 1 in glomerulonephritis
por: Park, Sehoon, et al.
Publicado: (2022)

Erratum to "Cripto Enhances Proliferation and Survival of Mesenchymal Stem Cells by Up-Regulating JAK2/STAT3 Pathway in a GRP78-Dependent Manner" [Biomol. Ther. 26 (2018) 464-473]
por: Yun, SeungPil, et al.
Publicado: (2021)

C-Jun N-terminal kinase inhibitors: Structural insight into kinase-inhibitor complexes
por: Duong, Men Thi Hoai, et al.
Publicado: (2020)

Immunohistochemical Expression of Dual-Specificity Protein Phosphatase 4 in Patients with Colorectal Adenocarcinoma
por: Sim, Jongmin, et al.
Publicado: (2015)

Potential use of mesenchymal stem cells in human meniscal repair: current insights
por: Pak, Jaewoo, et al.
Publicado: (2017)

Dual‐Specificity Phosphatase 26 Protects Against Cardiac Hypertrophy Through TAK1
por: Zhao, Jing, et al.
Publicado: (2021)

Global Dissemination of Carbapenemase-Producing Klebsiella pneumoniae: Epidemiology, Genetic Context, Treatment Options, and Detection Methods
por: Lee, Chang-Ro, et al.
Publicado: (2016)

RPTPμ tyrosine phosphatase promotes adipogenic differentiation via modulation of p120 catenin phosphorylation
por: Kim, Won Kon, et al.
Publicado: (2011)

Emerging roles of PHLPP phosphatases in metabolism
por: Cha, Jong-Ho, et al.
Publicado: (2021)

Transduodenal ampullectomy for ampullary tumors – single center experience of consecutive 26 patients
por: Hong, Sarang, et al.
Publicado: (2018)

Comparison of the Efficacy and Safety of Sodium Phosphate Tablets and Polyethylene Glycol Solution for Bowel Cleansing in Healthy Korean Adults
por: Lee, Seung-Hwa, et al.
Publicado: (2014)

A Randomized Controlled Trial of Comparison on Time and Rate of Cecal and Termianl Ileal Intubation according to Adult-Colonoscope Length: Intermediate versus Long
por: Kim, Kwang-Min, et al.
Publicado: (2014)

Dual-responsive Gemini Micelles for Efficient Delivery of Anticancer Therapeutics
por: Choi, Young In, et al.
Publicado: (2019)

The Role of Oxidative Inactivation of Phosphatase PTEN and TCPTP in Fatty Liver Disease
por: Nguyen Huu, Thang, et al.
Publicado: (2023)

Identification of DNA Aptamers toward Epithelial Cell Adhesion Molecule via Cell-SELEX
por: Kim, Ji Won, et al.
Publicado: (2014)

Severe persistent hypocholesterolemia after emergency gastrointestinal surgery predicts in-hospital mortality in critically ill patients with diffuse peritonitis
por: Lee, Seung Hwan, et al.
Publicado: (2018)

Critical Roles of Dual-Specificity Phosphatases in Neuronal Proteostasis and Neurological Diseases
por: Bhore, Noopur, et al.
Publicado: (2017)

Transcatheter coil embolization of the inferior epigastric artery in a huge abdominal wall hematoma caused by paracentesis in a patient with liver cirrhosis
por: Park, Yun Ji, et al.
Publicado: (2011)

Journey of a Swallowed Toothbrush to the Colon
por: Kim, In Hee, et al.
Publicado: (2007)

Uptake of liquid from wet surfaces by the brush-tipped proboscis of a butterfly
por: Lee, Seung Chul, et al.
Publicado: (2014)

An unusual complication of pyloric ring obstruction caused by flange of lumen apposing metal stent in endoscopic ultrasound-guided gallbladder drainage: A case report
por: Seo, Seung Young, et al.
Publicado: (2020)

Dual Monitoring of Cracking and Healing in Self-healing Coatings Using Microcapsules Loaded with Two Fluorescent Dyes
por: Song, Young Kyu, et al.
Publicado: (2019)

Extracellular proteolytic activation of Pseudomonas aeruginosa aminopeptidase (PaAP) and insight into the role of its non-catalytic N-terminal domain
por: Axelrad, Itschak, et al.
Publicado: (2021)

Ssu72 Dual-Specific Protein Phosphatase: From Gene to Diseases
por: Hwang, Soeun, et al.
Publicado: (2021)

Modeling catalytic promiscuity in the alkaline phosphatase superfamily
por: Duarte, Fernanda, et al.
Publicado: (2013)

Structural Insights into Protein Regulation by Phosphorylation and Substrate Recognition of Protein Kinases/Phosphatases
por: Seok, Seung-Hyeon
Publicado: (2021)

Quantitative proteomic view associated with resistance to clinically important antibiotics in Gram-positive bacteria: a systematic review
por: Lee, Chang-Ro, et al.
Publicado: (2015)

Optimized enzymatic dual functions of PaPrx protein by proton irradiation
por: Park, Chul-Hong, et al.
Publicado: (2014)

Quercetin induces dual specificity phosphatase 5 via serum response factor
por: Boonruang, Kanokkan, et al.
Publicado: (2023)

Regeneration of Cartilage in Human Knee Osteoarthritis with Autologous Adipose Tissue-Derived Stem Cells and Autologous Extracellular Matrix
por: Pak, Jaewoo, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_m348cvrbegn2csi2pn75l5e95e