Differential Effects of Long Term FTY720 Treatment on Endothelial versus Smooth Muscle Cell Signaling to S1P in Rat Mesenteric Arteries

The sphingosine-1-phosphate (S1P) analog FTY720 exerts pleiotropic effects on the cardiovascular system and causes down-regulation of S1P receptors. Myogenic constriction is an important mechanism regulating resistance vessel function and is known to be modulated by S1P. Here we investigated myogeni...

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Detalles Bibliográficos
Autores principales: Hamidi Shishavan, Mahdi, Bidadkosh, Arash, Yazdani, Saleh, Lambooy, Sebastiaan, van den Born, Jacob, Buikema, Hendrik, Henning, Robert H., Deelman, Leo E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008781/
https://www.ncbi.nlm.nih.gov/pubmed/27583547
http://dx.doi.org/10.1371/journal.pone.0162029

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008781/
https://www.ncbi.nlm.nih.gov/pubmed/27583547
http://dx.doi.org/10.1371/journal.pone.0162029

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