SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes

Recruitment of the deubiquitinase CYLD to signaling complexes is mediated by its interaction with HOIP, the catalytically active component of the linear ubiquitin chain assembly complex (LUBAC). Here, we identify SPATA2 as a constitutive direct binding partner of HOIP that bridges the interaction be...

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Detalles Bibliográficos
Autores principales: Kupka, Sebastian, De Miguel, Diego, Draber, Peter, Martino, Luigi, Surinova, Silvia, Rittinger, Katrin, Walczak, Henning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2016
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009064/
https://www.ncbi.nlm.nih.gov/pubmed/27545878
http://dx.doi.org/10.1016/j.celrep.2016.07.086

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