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Treatment response after radioembolisation in patients with hepatocellular carcinoma—An evaluation with dual energy computed-tomography

PURPOSE: The aim of this prospective study was to examine the diagnostic value of dual-energy CT (DECT) in the assessment of response of HCC after radioembolisation (RE). MATERIAL AND METHODS: 40 HCC patients with 82 measurable target lesions were included in this study. At baseline and follow-up ex...

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Autores principales: Altenbernd, Jens, Wetter, Axel, Forsting, Michael, Umutlu, Lale
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009187/
https://www.ncbi.nlm.nih.gov/pubmed/27622200
http://dx.doi.org/10.1016/j.ejro.2016.08.002
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author Altenbernd, Jens
Wetter, Axel
Forsting, Michael
Umutlu, Lale
author_facet Altenbernd, Jens
Wetter, Axel
Forsting, Michael
Umutlu, Lale
author_sort Altenbernd, Jens
collection PubMed
description PURPOSE: The aim of this prospective study was to examine the diagnostic value of dual-energy CT (DECT) in the assessment of response of HCC after radioembolisation (RE). MATERIAL AND METHODS: 40 HCC patients with 82 measurable target lesions were included in this study. At baseline and follow-up examination target lesions were evaluated with (IU), AASLD and Choi measurement criteria. Disease control was defined as the sum of complete response (CR), partial response (PR), progression disease (PD) and stable disease (SD). RESULTS: With Choi and IU more patients were considered than PR and less than PD and SD. According to AASLD more patients were measured as SD and PD than PR. 26/40 patients were classified as PR with IU. In contrast measurements with AASLD in only 8/26 patients were also classified as PR. 6/12 SD patients measured with IU were measured as PD with AASLD. 4/26 patients classified with IU as PR were described as SD with CHOI, 10/14 SD patients measured with CHOI were SD according to IU, the other 4 patients were PR with IU. 2/4 PD patients according to CHOI were SD with IU. CONCLUSION: More patients by IU were classified as SD versus PD and PR versus SD. We attribute this to the more detailed consideration of the HU differences between the virtual native and contrast-enhanced series generated by DECT. Iodine uptake (IU) in HCC measured and visualized with DECT is a promising imaging method for the assessment of treatment response after radioembolisations. KEY POINTS: —dual energy CT of hypervascular tumors such as HCC allows to quantify contrast enhancement without native imaging. —this can be used to evaluate the therapy response after Radioembolization.
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spelling pubmed-50091872016-09-12 Treatment response after radioembolisation in patients with hepatocellular carcinoma—An evaluation with dual energy computed-tomography Altenbernd, Jens Wetter, Axel Forsting, Michael Umutlu, Lale Eur J Radiol Open Article PURPOSE: The aim of this prospective study was to examine the diagnostic value of dual-energy CT (DECT) in the assessment of response of HCC after radioembolisation (RE). MATERIAL AND METHODS: 40 HCC patients with 82 measurable target lesions were included in this study. At baseline and follow-up examination target lesions were evaluated with (IU), AASLD and Choi measurement criteria. Disease control was defined as the sum of complete response (CR), partial response (PR), progression disease (PD) and stable disease (SD). RESULTS: With Choi and IU more patients were considered than PR and less than PD and SD. According to AASLD more patients were measured as SD and PD than PR. 26/40 patients were classified as PR with IU. In contrast measurements with AASLD in only 8/26 patients were also classified as PR. 6/12 SD patients measured with IU were measured as PD with AASLD. 4/26 patients classified with IU as PR were described as SD with CHOI, 10/14 SD patients measured with CHOI were SD according to IU, the other 4 patients were PR with IU. 2/4 PD patients according to CHOI were SD with IU. CONCLUSION: More patients by IU were classified as SD versus PD and PR versus SD. We attribute this to the more detailed consideration of the HU differences between the virtual native and contrast-enhanced series generated by DECT. Iodine uptake (IU) in HCC measured and visualized with DECT is a promising imaging method for the assessment of treatment response after radioembolisations. KEY POINTS: —dual energy CT of hypervascular tumors such as HCC allows to quantify contrast enhancement without native imaging. —this can be used to evaluate the therapy response after Radioembolization. Elsevier 2016-08-25 /pmc/articles/PMC5009187/ /pubmed/27622200 http://dx.doi.org/10.1016/j.ejro.2016.08.002 Text en © 2016 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Altenbernd, Jens
Wetter, Axel
Forsting, Michael
Umutlu, Lale
Treatment response after radioembolisation in patients with hepatocellular carcinoma—An evaluation with dual energy computed-tomography
title Treatment response after radioembolisation in patients with hepatocellular carcinoma—An evaluation with dual energy computed-tomography
title_full Treatment response after radioembolisation in patients with hepatocellular carcinoma—An evaluation with dual energy computed-tomography
title_fullStr Treatment response after radioembolisation in patients with hepatocellular carcinoma—An evaluation with dual energy computed-tomography
title_full_unstemmed Treatment response after radioembolisation in patients with hepatocellular carcinoma—An evaluation with dual energy computed-tomography
title_short Treatment response after radioembolisation in patients with hepatocellular carcinoma—An evaluation with dual energy computed-tomography
title_sort treatment response after radioembolisation in patients with hepatocellular carcinoma—an evaluation with dual energy computed-tomography
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009187/
https://www.ncbi.nlm.nih.gov/pubmed/27622200
http://dx.doi.org/10.1016/j.ejro.2016.08.002
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