The characterization of an intestine-like genomic signature maintained during Barrett’s-associated adenocarcinogenesis reveals an NR5A2-mediated promotion of cancer cell survival

Barrett’s oesophagus (BO), an intestinal-type metaplasia (IM), typically arising in conjunction with gastro-oesophageal reflux disease, is a prominent risk factor for the development of oesophageal adenocarcinoma (OAC). The molecular similarities between IM and normal intestinal tissues are ill-defi...

Descripción completa

Detalles Bibliográficos
Autores principales: Duggan, Shane P., Behan, Fiona M., Kirca, Murat, Zaheer, Abdul, McGarrigle, Sarah A., Reynolds, John V., Vaz, Gisela M. F., Senge, Mathias O., Kelleher, Dermot
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009315/
https://www.ncbi.nlm.nih.gov/pubmed/27586588
http://dx.doi.org/10.1038/srep32638

Ejemplares similares

Ejemplares similares