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In vivo evidence for translesion synthesis by the replicative DNA polymerase δ

The intolerance of DNA polymerase δ (Polδ) to incorrect base pairing contributes to its extremely high accuracy during replication, but is believed to inhibit translesion synthesis (TLS). However, chicken DT40 cells lacking the POLD3 subunit of Polδ are deficient in TLS. Previous genetic and biochem...

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Detalles Bibliográficos
Autores principales:	Hirota, Kouji, Tsuda, Masataka, Mohiuddin, Tsurimoto, Toshiki, Cohen, Isadora S., Livneh, Zvi, Kobayashi, Kaori, Narita, Takeo, Nishihara, Kana, Murai, Junko, Iwai, Shigenori, Guilbaud, Guillaume, Sale, Julian E., Takeda, Shunichi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2016
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009730/ https://www.ncbi.nlm.nih.gov/pubmed/27185888 http://dx.doi.org/10.1093/nar/gkw439

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