Annexin A2 facilitates endocytic trafficking of antisense oligonucleotides

Chemically modified antisense oligonucleotides (ASOs) designed to mediate site-specific cleavage of RNA by RNase H1 are used as research tools and as therapeutics. ASOs modified with phosphorothioate (PS) linkages enter cells via endocytotic pathways. The mechanisms by which PS-ASOs are released fro...

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Detalles Bibliográficos
Autores principales: Wang, Shiyu, Sun, Hong, Tanowitz, Michael, Liang, Xue-hai, Crooke, Stanley T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009748/
https://www.ncbi.nlm.nih.gov/pubmed/27378781
http://dx.doi.org/10.1093/nar/gkw595

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009748/
https://www.ncbi.nlm.nih.gov/pubmed/27378781
http://dx.doi.org/10.1093/nar/gkw595

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