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Cyclic mismatch binding ligand CMBL4 binds to the 5′-T-3′/5′-GG-3′ site by inducing the flipping out of thymine base

A newly designed cyclic bis-naphthyridine carbamate dimer CMBL4 with a limited conformational flexibility was synthesized and characterized. Absorption spectra revealed that two naphthyridines in CMBL4 were stacked on each other in aqueous solutions. The most efficient binding of CMBL4 to DNA was ob...

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Detalles Bibliográficos
Autores principales:	Mukherjee, Sanjukta, Dohno, Chikara, Asano, Kaori, Nakatani, Kazuhiko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2016
Materias:	Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009760/ https://www.ncbi.nlm.nih.gov/pubmed/27466390 http://dx.doi.org/10.1093/nar/gkw672

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