A new hERG allosteric modulator rescues genetic and drug‐induced long‐QT syndrome phenotypes in cardiomyocytes from isogenic pairs of patient induced pluripotent stem cells

Long‐QT syndrome (LQTS) is an arrhythmogenic disorder characterised by prolongation of the QT interval in the electrocardiogram, which can lead to sudden cardiac death. Pharmacological treatments are far from optimal for congenital forms of LQTS, while the acquired form, often triggered by drugs tha...

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Detalles Bibliográficos
Autores principales: Sala, Luca, Yu, Zhiyi, Ward‐van Oostwaard, Dorien, van Veldhoven, Jacobus PD, Moretti, Alessandra, Laugwitz, Karl‐Ludwig, Mummery, Christine L, IJzerman, Adriaan P, Bellin, Milena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009811/
https://www.ncbi.nlm.nih.gov/pubmed/27470144
http://dx.doi.org/10.15252/emmm.201606260

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