Blocking sense‐strand activity improves potency, safety and specificity of anti‐hepatitis B virus short hairpin RNA

Hepatitis B virus (HBV) is a promising target for therapies based on RNA interference (RNAi) since it replicates via RNA transcripts that are vulnerable to RNAi silencing. Clinical translation of RNAi technology, however, requires improvements in potency, specificity and safety. To this end, we syst...

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Detalles Bibliográficos
Autores principales: Michler, Thomas, Große, Stefanie, Mockenhaupt, Stefan, Röder, Natalie, Stückler, Ferdinand, Knapp, Bettina, Ko, Chunkyu, Heikenwalder, Mathias, Protzer, Ulrike, Grimm, Dirk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009812/
https://www.ncbi.nlm.nih.gov/pubmed/27473329
http://dx.doi.org/10.15252/emmm.201506172

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