The anti-NGF antibody muMab 911 both prevents and reverses pain behaviour and subchondral osteoclast numbers in a rat model of osteoarthritis pain

OBJECTIVE: Nerve growth factor (NGF) has a pivotal role in peripheral hyperalgesia and inflammation; anti-NGF antibodies attenuate pain responses in inflammatory pain models, and in people with osteoarthritis (OA) or low back pain. The aim of this study was to characterise the peripheral mechanisms...

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Detalles Bibliográficos
Autores principales: Xu, L., Nwosu, L.N., Burston, J.J., Millns, P.J., Sagar, D.R., Mapp, P.I., Meesawatsom, P., Li, L., Bennett, A.J., Walsh, D.A., Chapman, V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: W.B. Saunders For The Osteoarthritis Research Society 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009895/
https://www.ncbi.nlm.nih.gov/pubmed/27208420
http://dx.doi.org/10.1016/j.joca.2016.05.015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009895/
https://www.ncbi.nlm.nih.gov/pubmed/27208420
http://dx.doi.org/10.1016/j.joca.2016.05.015

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