Enzyme-Regulated Supramolecular Assemblies of Cholesterol Conjugates against Drug-Resistant Ovarian Cancer Cells

[Image: see text] We report that phosphotyrosine–cholesterol conjugates effectively and selectively kill cancer cells, including platinum-resistant ovarian cancer cells. The conjugate increases the degree of noncovalent oligomerization upon enzymatic dephosphorylation in aqueous buffer. This enzymat...

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Detalles Bibliográficos
Autores principales: Wang, Huaimin, Feng, Zhaoqianqi, Wu, Dongdong, Fritzsching, Keith J., Rigney, Mike, Zhou, Jie, Jiang, Yujie, Schmidt-Rohr, Klaus, Xu, Bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2016
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010010/
https://www.ncbi.nlm.nih.gov/pubmed/27529637
http://dx.doi.org/10.1021/jacs.6b06075

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