Phosphorylation of residues inside the SNARE complex suppresses secretory vesicle fusion

Membrane fusion is essential for eukaryotic life, requiring SNARE proteins to zipper up in an α‐helical bundle to pull two membranes together. Here, we show that vesicle fusion can be suppressed by phosphorylation of core conserved residues inside the SNARE domain. We took a proteomics approach usin...

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Detalles Bibliográficos
Autores principales: Malmersjö, Seth, Di Palma, Serena, Diao, Jiajie, Lai, Ying, Pfuetzner, Richard A, Wang, Austin L, McMahon, Moira A, Hayer, Arnold, Porteus, Matthew, Bodenmiller, Bernd, Brunger, Axel T, Meyer, Tobias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010044/
https://www.ncbi.nlm.nih.gov/pubmed/27402227
http://dx.doi.org/10.15252/embj.201694071

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