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MR Parametric Mapping as a Biomarker of Early Joint Degeneration
CONTEXT: Osteoarthritis (OA) is a common, worldwide disorder. Magnetic resonance (MR) imaging can directly and noninvasively evaluate articular cartilage and has emerged as an essential tool in the study of OA. EVIDENCE ACQUISITION: A PubMed search was performed using the keywords quantitative MRI a...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010134/ https://www.ncbi.nlm.nih.gov/pubmed/27488128 http://dx.doi.org/10.1177/1941738116661975 |
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author | Chang, Eric Y. Ma, Yajun Du, Jiang |
author_facet | Chang, Eric Y. Ma, Yajun Du, Jiang |
author_sort | Chang, Eric Y. |
collection | PubMed |
description | CONTEXT: Osteoarthritis (OA) is a common, worldwide disorder. Magnetic resonance (MR) imaging can directly and noninvasively evaluate articular cartilage and has emerged as an essential tool in the study of OA. EVIDENCE ACQUISITION: A PubMed search was performed using the keywords quantitative MRI and cartilage. No limits were set on the range of years searched. Articles were reviewed for relevance with an emphasis on in vivo studies performed at 3 tesla. STUDY DESIGN: Clinical review. LEVEL OF EVIDENCE: Level 4. RESULTS: T2, T2*, T1 (particularly when measured after exogenous contrast administration, such as with the delayed gadolinium-enhanced MR imaging of cartilage [dGEMRIC] technique), and T1ρ are among the most widely utilized quantitative MR imaging techniques to evaluate cartilage and have been implemented in various patient cohorts. Existing challenges include reproducibility of results, insufficient consensus regarding optimal sequences and parameters, and interpretation of values. CONCLUSION: Quantitative assessment of cartilage using MR imaging techniques likely represents the best opportunity to identify early cartilage degeneration and to follow patients after treatment. Despite existing challenges, ongoing work and unique approaches have shown exciting and promising results. |
format | Online Article Text |
id | pubmed-5010134 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-50101342017-09-01 MR Parametric Mapping as a Biomarker of Early Joint Degeneration Chang, Eric Y. Ma, Yajun Du, Jiang Sports Health Focus Topic: Update on Imaging CONTEXT: Osteoarthritis (OA) is a common, worldwide disorder. Magnetic resonance (MR) imaging can directly and noninvasively evaluate articular cartilage and has emerged as an essential tool in the study of OA. EVIDENCE ACQUISITION: A PubMed search was performed using the keywords quantitative MRI and cartilage. No limits were set on the range of years searched. Articles were reviewed for relevance with an emphasis on in vivo studies performed at 3 tesla. STUDY DESIGN: Clinical review. LEVEL OF EVIDENCE: Level 4. RESULTS: T2, T2*, T1 (particularly when measured after exogenous contrast administration, such as with the delayed gadolinium-enhanced MR imaging of cartilage [dGEMRIC] technique), and T1ρ are among the most widely utilized quantitative MR imaging techniques to evaluate cartilage and have been implemented in various patient cohorts. Existing challenges include reproducibility of results, insufficient consensus regarding optimal sequences and parameters, and interpretation of values. CONCLUSION: Quantitative assessment of cartilage using MR imaging techniques likely represents the best opportunity to identify early cartilage degeneration and to follow patients after treatment. Despite existing challenges, ongoing work and unique approaches have shown exciting and promising results. SAGE Publications 2016-08-03 2016-09 /pmc/articles/PMC5010134/ /pubmed/27488128 http://dx.doi.org/10.1177/1941738116661975 Text en © 2016 The Author(s) |
spellingShingle | Focus Topic: Update on Imaging Chang, Eric Y. Ma, Yajun Du, Jiang MR Parametric Mapping as a Biomarker of Early Joint Degeneration |
title | MR Parametric Mapping as a Biomarker of Early Joint Degeneration |
title_full | MR Parametric Mapping as a Biomarker of Early Joint Degeneration |
title_fullStr | MR Parametric Mapping as a Biomarker of Early Joint Degeneration |
title_full_unstemmed | MR Parametric Mapping as a Biomarker of Early Joint Degeneration |
title_short | MR Parametric Mapping as a Biomarker of Early Joint Degeneration |
title_sort | mr parametric mapping as a biomarker of early joint degeneration |
topic | Focus Topic: Update on Imaging |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010134/ https://www.ncbi.nlm.nih.gov/pubmed/27488128 http://dx.doi.org/10.1177/1941738116661975 |
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