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MR Parametric Mapping as a Biomarker of Early Joint Degeneration

CONTEXT: Osteoarthritis (OA) is a common, worldwide disorder. Magnetic resonance (MR) imaging can directly and noninvasively evaluate articular cartilage and has emerged as an essential tool in the study of OA. EVIDENCE ACQUISITION: A PubMed search was performed using the keywords quantitative MRI a...

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Autores principales: Chang, Eric Y., Ma, Yajun, Du, Jiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010134/
https://www.ncbi.nlm.nih.gov/pubmed/27488128
http://dx.doi.org/10.1177/1941738116661975
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author Chang, Eric Y.
Ma, Yajun
Du, Jiang
author_facet Chang, Eric Y.
Ma, Yajun
Du, Jiang
author_sort Chang, Eric Y.
collection PubMed
description CONTEXT: Osteoarthritis (OA) is a common, worldwide disorder. Magnetic resonance (MR) imaging can directly and noninvasively evaluate articular cartilage and has emerged as an essential tool in the study of OA. EVIDENCE ACQUISITION: A PubMed search was performed using the keywords quantitative MRI and cartilage. No limits were set on the range of years searched. Articles were reviewed for relevance with an emphasis on in vivo studies performed at 3 tesla. STUDY DESIGN: Clinical review. LEVEL OF EVIDENCE: Level 4. RESULTS: T2, T2*, T1 (particularly when measured after exogenous contrast administration, such as with the delayed gadolinium-enhanced MR imaging of cartilage [dGEMRIC] technique), and T1ρ are among the most widely utilized quantitative MR imaging techniques to evaluate cartilage and have been implemented in various patient cohorts. Existing challenges include reproducibility of results, insufficient consensus regarding optimal sequences and parameters, and interpretation of values. CONCLUSION: Quantitative assessment of cartilage using MR imaging techniques likely represents the best opportunity to identify early cartilage degeneration and to follow patients after treatment. Despite existing challenges, ongoing work and unique approaches have shown exciting and promising results.
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spelling pubmed-50101342017-09-01 MR Parametric Mapping as a Biomarker of Early Joint Degeneration Chang, Eric Y. Ma, Yajun Du, Jiang Sports Health Focus Topic: Update on Imaging CONTEXT: Osteoarthritis (OA) is a common, worldwide disorder. Magnetic resonance (MR) imaging can directly and noninvasively evaluate articular cartilage and has emerged as an essential tool in the study of OA. EVIDENCE ACQUISITION: A PubMed search was performed using the keywords quantitative MRI and cartilage. No limits were set on the range of years searched. Articles were reviewed for relevance with an emphasis on in vivo studies performed at 3 tesla. STUDY DESIGN: Clinical review. LEVEL OF EVIDENCE: Level 4. RESULTS: T2, T2*, T1 (particularly when measured after exogenous contrast administration, such as with the delayed gadolinium-enhanced MR imaging of cartilage [dGEMRIC] technique), and T1ρ are among the most widely utilized quantitative MR imaging techniques to evaluate cartilage and have been implemented in various patient cohorts. Existing challenges include reproducibility of results, insufficient consensus regarding optimal sequences and parameters, and interpretation of values. CONCLUSION: Quantitative assessment of cartilage using MR imaging techniques likely represents the best opportunity to identify early cartilage degeneration and to follow patients after treatment. Despite existing challenges, ongoing work and unique approaches have shown exciting and promising results. SAGE Publications 2016-08-03 2016-09 /pmc/articles/PMC5010134/ /pubmed/27488128 http://dx.doi.org/10.1177/1941738116661975 Text en © 2016 The Author(s)
spellingShingle Focus Topic: Update on Imaging
Chang, Eric Y.
Ma, Yajun
Du, Jiang
MR Parametric Mapping as a Biomarker of Early Joint Degeneration
title MR Parametric Mapping as a Biomarker of Early Joint Degeneration
title_full MR Parametric Mapping as a Biomarker of Early Joint Degeneration
title_fullStr MR Parametric Mapping as a Biomarker of Early Joint Degeneration
title_full_unstemmed MR Parametric Mapping as a Biomarker of Early Joint Degeneration
title_short MR Parametric Mapping as a Biomarker of Early Joint Degeneration
title_sort mr parametric mapping as a biomarker of early joint degeneration
topic Focus Topic: Update on Imaging
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010134/
https://www.ncbi.nlm.nih.gov/pubmed/27488128
http://dx.doi.org/10.1177/1941738116661975
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