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Regulation of the host immune system by helminth parasites
Helminth parasite infections are associated with a battery of immunomodulatory mechanisms that affect all facets of the host immune response to ensure their persistence within the host. This broad-spectrum modulation of host immunity has intended and unintended consequences, both advantageous and di...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Mosby
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010150/ https://www.ncbi.nlm.nih.gov/pubmed/27476889 http://dx.doi.org/10.1016/j.jaci.2016.07.007 |
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author | Maizels, Rick M. McSorley, Henry J. |
author_facet | Maizels, Rick M. McSorley, Henry J. |
author_sort | Maizels, Rick M. |
collection | PubMed |
description | Helminth parasite infections are associated with a battery of immunomodulatory mechanisms that affect all facets of the host immune response to ensure their persistence within the host. This broad-spectrum modulation of host immunity has intended and unintended consequences, both advantageous and disadvantageous. Thus the host can benefit from suppression of collateral damage during parasite infection and from reduced allergic, autoimmune, and inflammatory reactions. However, helminth infection can also be detrimental in reducing vaccine responses, increasing susceptibility to coinfection and potentially reducing tumor immunosurveillance. In this review we will summarize the panoply of immunomodulatory mechanisms used by helminths, their potential utility in human disease, and prospective areas of future research. |
format | Online Article Text |
id | pubmed-5010150 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Mosby |
record_format | MEDLINE/PubMed |
spelling | pubmed-50101502016-09-06 Regulation of the host immune system by helminth parasites Maizels, Rick M. McSorley, Henry J. J Allergy Clin Immunol Reviews and Feature Article Helminth parasite infections are associated with a battery of immunomodulatory mechanisms that affect all facets of the host immune response to ensure their persistence within the host. This broad-spectrum modulation of host immunity has intended and unintended consequences, both advantageous and disadvantageous. Thus the host can benefit from suppression of collateral damage during parasite infection and from reduced allergic, autoimmune, and inflammatory reactions. However, helminth infection can also be detrimental in reducing vaccine responses, increasing susceptibility to coinfection and potentially reducing tumor immunosurveillance. In this review we will summarize the panoply of immunomodulatory mechanisms used by helminths, their potential utility in human disease, and prospective areas of future research. Mosby 2016-09 /pmc/articles/PMC5010150/ /pubmed/27476889 http://dx.doi.org/10.1016/j.jaci.2016.07.007 Text en © 2016 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Reviews and Feature Article Maizels, Rick M. McSorley, Henry J. Regulation of the host immune system by helminth parasites |
title | Regulation of the host immune system by helminth parasites |
title_full | Regulation of the host immune system by helminth parasites |
title_fullStr | Regulation of the host immune system by helminth parasites |
title_full_unstemmed | Regulation of the host immune system by helminth parasites |
title_short | Regulation of the host immune system by helminth parasites |
title_sort | regulation of the host immune system by helminth parasites |
topic | Reviews and Feature Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010150/ https://www.ncbi.nlm.nih.gov/pubmed/27476889 http://dx.doi.org/10.1016/j.jaci.2016.07.007 |
work_keys_str_mv | AT maizelsrickm regulationofthehostimmunesystembyhelminthparasites AT mcsorleyhenryj regulationofthehostimmunesystembyhelminthparasites |