Gain- and Loss-of-Function Mutations in the Breast Cancer Gene GATA3 Result in Differential Drug Sensitivity

Patterns of somatic mutations in cancer genes provide information about their functional role in tumourigenesis, and thus indicate their potential for therapeutic exploitation. Yet, the classical distinction between oncogene and tumour suppressor may not always apply. For instance, TP53 has been sim...

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Detalles Bibliográficos
Autores principales: Mair, Barbara, Konopka, Tomasz, Kerzendorfer, Claudia, Sleiman, Katia, Salic, Sejla, Serra, Violeta, Muellner, Markus K., Theodorou, Vasiliki, Nijman, Sebastian M. B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010247/
https://www.ncbi.nlm.nih.gov/pubmed/27588951
http://dx.doi.org/10.1371/journal.pgen.1006279

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