Conformational Changes in the Epidermal Growth Factor Receptor: Role of the Transmembrane Domain Investigated by Coarse-Grained MetaDynamics Free Energy Calculations

[Image: see text] The epidermal growth factor receptor (EGFR) is a dimeric membrane protein that regulates key aspects of cellular function. Activation of the EGFR is linked to changes in the conformation of the transmembrane (TM) domain, brought about by changes in interactions of the TM helices of...

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Detalles Bibliográficos
Autores principales: Lelimousin, Mickaël, Limongelli, Vittorio, Sansom, Mark S. P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2016
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010359/
https://www.ncbi.nlm.nih.gov/pubmed/27459426
http://dx.doi.org/10.1021/jacs.6b05602

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010359/
https://www.ncbi.nlm.nih.gov/pubmed/27459426
http://dx.doi.org/10.1021/jacs.6b05602

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