Cargando…

A Statewide Nested Case–Control Study of Preterm Birth and Air Pollution by Source and Composition: California, 2001–2008

BACKGROUND: Preterm birth (PTB) has been associated with exposure to air pollution, but it is unclear whether effects might vary among air pollution sources and components. OBJECTIVES: We studied the relationships between PTB and exposure to different components of air pollution, including gases and...

Descripción completa

Detalles Bibliográficos
Autores principales: Laurent, Olivier, Hu, Jianlin, Li, Lianfa, Kleeman, Michael J., Bartell, Scott M., Cockburn, Myles, Escobedo, Loraine, Wu, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Institute of Environmental Health Sciences 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010414/
https://www.ncbi.nlm.nih.gov/pubmed/26895492
http://dx.doi.org/10.1289/ehp.1510133
_version_ 1782451688159838208
author Laurent, Olivier
Hu, Jianlin
Li, Lianfa
Kleeman, Michael J.
Bartell, Scott M.
Cockburn, Myles
Escobedo, Loraine
Wu, Jun
author_facet Laurent, Olivier
Hu, Jianlin
Li, Lianfa
Kleeman, Michael J.
Bartell, Scott M.
Cockburn, Myles
Escobedo, Loraine
Wu, Jun
author_sort Laurent, Olivier
collection PubMed
description BACKGROUND: Preterm birth (PTB) has been associated with exposure to air pollution, but it is unclear whether effects might vary among air pollution sources and components. OBJECTIVES: We studied the relationships between PTB and exposure to different components of air pollution, including gases and particulate matter (PM) by size fraction, chemical composition, and sources. METHODS: Fine and ultrafine PM (respectively, PM2.5 and PM0.1) by source and composition were modeled across California over 2000–2008. Measured PM2.5, nitrogen dioxide, and ozone concentrations were spatially interpolated using empirical Bayesian kriging. Primary traffic emissions at fine scale were modeled using CALINE4 and traffic indices. Data on maternal characteristics, pregnancies, and birth outcomes were obtained from birth certificates. Associations between PTB (n = 442,314) and air pollution exposures defined according to the maternal residence at birth were examined using a nested matched case–control approach. Analyses were adjusted for maternal age, race/ethnicity, education and neighborhood income. RESULTS: Adjusted odds ratios for PTB in association with interquartile range (IQR) increases in average exposure during pregnancy were 1.133 (95% CI: 1.118, 1.148) for total PM2.5, 1.096 (95% CI: 1.085, 1.108) for ozone, and 1.079 (95% CI: 1.065, 1.093) for nitrogen dioxide. For primary PM, the strongest associations per IQR by source were estimated for onroad gasoline (9–11% increase), followed by onroad diesel (6–8%) and commercial meat cooking (4–7%). For PM2.5 composition, the strongest positive associations per IQR were estimated for nitrate, ammonium, and secondary organic aerosols (11–14%), followed by elemental and organic carbon (2–4%). Associations with local traffic emissions were positive only when analyses were restricted to births with residences geocoded at the tax parcel level. CONCLUSIONS: In our statewide nested case–control study population, exposures to both primary and secondary pollutants were associated with an increase in PTB. CITATION: Laurent O, Hu J, Li L, Kleeman MJ, Bartell SM, Cockburn M, Escobedo L, Wu J. 2016. A statewide nested case–control study of preterm birth and air pollution by source and composition: California, 2001–2008. Environ Health Perspect 124:1479–1486; http://dx.doi.org/10.1289/ehp.1510133
format Online
Article
Text
id pubmed-5010414
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher National Institute of Environmental Health Sciences
record_format MEDLINE/PubMed
spelling pubmed-50104142016-09-13 A Statewide Nested Case–Control Study of Preterm Birth and Air Pollution by Source and Composition: California, 2001–2008 Laurent, Olivier Hu, Jianlin Li, Lianfa Kleeman, Michael J. Bartell, Scott M. Cockburn, Myles Escobedo, Loraine Wu, Jun Environ Health Perspect Children's Health BACKGROUND: Preterm birth (PTB) has been associated with exposure to air pollution, but it is unclear whether effects might vary among air pollution sources and components. OBJECTIVES: We studied the relationships between PTB and exposure to different components of air pollution, including gases and particulate matter (PM) by size fraction, chemical composition, and sources. METHODS: Fine and ultrafine PM (respectively, PM2.5 and PM0.1) by source and composition were modeled across California over 2000–2008. Measured PM2.5, nitrogen dioxide, and ozone concentrations were spatially interpolated using empirical Bayesian kriging. Primary traffic emissions at fine scale were modeled using CALINE4 and traffic indices. Data on maternal characteristics, pregnancies, and birth outcomes were obtained from birth certificates. Associations between PTB (n = 442,314) and air pollution exposures defined according to the maternal residence at birth were examined using a nested matched case–control approach. Analyses were adjusted for maternal age, race/ethnicity, education and neighborhood income. RESULTS: Adjusted odds ratios for PTB in association with interquartile range (IQR) increases in average exposure during pregnancy were 1.133 (95% CI: 1.118, 1.148) for total PM2.5, 1.096 (95% CI: 1.085, 1.108) for ozone, and 1.079 (95% CI: 1.065, 1.093) for nitrogen dioxide. For primary PM, the strongest associations per IQR by source were estimated for onroad gasoline (9–11% increase), followed by onroad diesel (6–8%) and commercial meat cooking (4–7%). For PM2.5 composition, the strongest positive associations per IQR were estimated for nitrate, ammonium, and secondary organic aerosols (11–14%), followed by elemental and organic carbon (2–4%). Associations with local traffic emissions were positive only when analyses were restricted to births with residences geocoded at the tax parcel level. CONCLUSIONS: In our statewide nested case–control study population, exposures to both primary and secondary pollutants were associated with an increase in PTB. CITATION: Laurent O, Hu J, Li L, Kleeman MJ, Bartell SM, Cockburn M, Escobedo L, Wu J. 2016. A statewide nested case–control study of preterm birth and air pollution by source and composition: California, 2001–2008. Environ Health Perspect 124:1479–1486; http://dx.doi.org/10.1289/ehp.1510133 National Institute of Environmental Health Sciences 2016-02-19 2016-09 /pmc/articles/PMC5010414/ /pubmed/26895492 http://dx.doi.org/10.1289/ehp.1510133 Text en http://creativecommons.org/publicdomain/mark/1.0/ Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged (for example, “Reproduced with permission from Environmental Health Perspectives”); pertinent reference information should be provided for the article from which the material was reproduced. Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright.
spellingShingle Children's Health
Laurent, Olivier
Hu, Jianlin
Li, Lianfa
Kleeman, Michael J.
Bartell, Scott M.
Cockburn, Myles
Escobedo, Loraine
Wu, Jun
A Statewide Nested Case–Control Study of Preterm Birth and Air Pollution by Source and Composition: California, 2001–2008
title A Statewide Nested Case–Control Study of Preterm Birth and Air Pollution by Source and Composition: California, 2001–2008
title_full A Statewide Nested Case–Control Study of Preterm Birth and Air Pollution by Source and Composition: California, 2001–2008
title_fullStr A Statewide Nested Case–Control Study of Preterm Birth and Air Pollution by Source and Composition: California, 2001–2008
title_full_unstemmed A Statewide Nested Case–Control Study of Preterm Birth and Air Pollution by Source and Composition: California, 2001–2008
title_short A Statewide Nested Case–Control Study of Preterm Birth and Air Pollution by Source and Composition: California, 2001–2008
title_sort statewide nested case–control study of preterm birth and air pollution by source and composition: california, 2001–2008
topic Children's Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010414/
https://www.ncbi.nlm.nih.gov/pubmed/26895492
http://dx.doi.org/10.1289/ehp.1510133
work_keys_str_mv AT laurentolivier astatewidenestedcasecontrolstudyofpretermbirthandairpollutionbysourceandcompositioncalifornia20012008
AT hujianlin astatewidenestedcasecontrolstudyofpretermbirthandairpollutionbysourceandcompositioncalifornia20012008
AT lilianfa astatewidenestedcasecontrolstudyofpretermbirthandairpollutionbysourceandcompositioncalifornia20012008
AT kleemanmichaelj astatewidenestedcasecontrolstudyofpretermbirthandairpollutionbysourceandcompositioncalifornia20012008
AT bartellscottm astatewidenestedcasecontrolstudyofpretermbirthandairpollutionbysourceandcompositioncalifornia20012008
AT cockburnmyles astatewidenestedcasecontrolstudyofpretermbirthandairpollutionbysourceandcompositioncalifornia20012008
AT escobedoloraine astatewidenestedcasecontrolstudyofpretermbirthandairpollutionbysourceandcompositioncalifornia20012008
AT wujun astatewidenestedcasecontrolstudyofpretermbirthandairpollutionbysourceandcompositioncalifornia20012008
AT laurentolivier statewidenestedcasecontrolstudyofpretermbirthandairpollutionbysourceandcompositioncalifornia20012008
AT hujianlin statewidenestedcasecontrolstudyofpretermbirthandairpollutionbysourceandcompositioncalifornia20012008
AT lilianfa statewidenestedcasecontrolstudyofpretermbirthandairpollutionbysourceandcompositioncalifornia20012008
AT kleemanmichaelj statewidenestedcasecontrolstudyofpretermbirthandairpollutionbysourceandcompositioncalifornia20012008
AT bartellscottm statewidenestedcasecontrolstudyofpretermbirthandairpollutionbysourceandcompositioncalifornia20012008
AT cockburnmyles statewidenestedcasecontrolstudyofpretermbirthandairpollutionbysourceandcompositioncalifornia20012008
AT escobedoloraine statewidenestedcasecontrolstudyofpretermbirthandairpollutionbysourceandcompositioncalifornia20012008
AT wujun statewidenestedcasecontrolstudyofpretermbirthandairpollutionbysourceandcompositioncalifornia20012008